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IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population

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Abstract

Esophageal cancer is the sixth leading cause of cancer-related deaths worldwide. Esophageal cancer is very aggressive; genetic polymorphisms may explain in part the individual differences in esophageal cancer susceptibility. We conducted a hospital based case–control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs) in the interleukin (IL)-15 and IL-15 receptor alpha (IL-15RA) gene on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscanTM kit. The IL-15RA rs2228059 A>C polymorphism was associated with a decreased risk of ESCC in a recessive genetic model; However, there was no significant association between the other five SNPs and ESCC risk. Stratified analyses indicated a significantly decreased risk of ESCC associated with the IL-15RA rs2228059 A>C polymorphism was evident among male, older, non-smoker, and non-drinker patients. These findings indicated that the functional polymorphism, IL-15RA rs2228059 A>C, might contribute to ESCC susceptibility. However, the statistical power of our study was limited because of the moderate sample size and absence of a validation cohort. Large well-designed studies are warranted to confirm our findings.

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Abbreviations

CI:

Confidential interval

IL-15RA :

Interleukin 15 receptor alpha

LD:

Linkage disequilibrium

OR:

Odds ratio

SNPs:

Single nucleotide polymorphisms

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Acknowledgments

We wish to thank Dr. Da Ding and Dr. Yan Liu (Genesky Biotechnologies Inc., Shanghai, China) for technical support. This study was supported in part by National Natural Science Foundation of China (81101889, 81000028), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481) and Social Development Foundation of Zhenjiang (SH2010017).

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Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China

    Jun Yin, Yijun Shi, Aizhong Shao, Weifeng Tang, Xu Wang, Guowen Ding, Chao Liu, Suocheng Chen & Haiyong Gu

  2. Department of Chemotherapy, Medicine Cancer Institute, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China

    Liming Wang

  3. Department of General Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 210029, China

    Wenbo Zhang

  4. Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yijang Chen

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  1. Jun Yin
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  2. Liming Wang
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  3. Yijun Shi
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  4. Aizhong Shao
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  9. Chao Liu
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Correspondence to Suocheng Chen or Haiyong Gu.

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Jun Yin and Liming Wang have contributed equally to this work.

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Yin, J., Wang, L., Shi, Y. et al. IL-15 receptor alpha rs2228059 A>C polymorphism was associated with a decreased risk of esophageal cancer in a Chinese population. Mol Biol Rep 41, 1951–1957 (2014). https://doi.org/10.1007/s11033-014-3042-8

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  • DOI: https://doi.org/10.1007/s11033-014-3042-8

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