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Inhibitor IκBα promoter functional polymorphisms in patients with multiple sclerosis

Molecular Biology Reports volume 41, pages 613–616 (2014)Cite this article

Abstract

The aim of this study is to investigate the association of IκBα promoter polymorphisms with the development of Multiple Sclerosis (MS) disease in Iranian population. One hundred and fifty patients with MS along with 150 unrelated healthy controls were enrolled in this study. The IκBα −881A/G (rs3138053), −826C/T (rs2233406) and −519C/T (rs2233408) polymorphisms were determined by the polymerase chain reaction/restriction fragment length polymorphism method. This study demonstrated that the genotype frequencies of IκBα −881A/G and −826T/T, and allele frequencies of IκBα−881G were significantly higher in patients with MS with respect to as compared to the controls. We also found that the estimated haplotype frequency of IκBα promoter −881G–826T–519C was significantly increased in the patient with MS in comparison with that of the healthy individuals. This study reveals that polymorphisms in the IκBα promoter (−881 A/G, −826 C/T) are strongly associated with the susceptibility of Iranian MS patients.

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Acknowledgments

This study was supported by Tarbiat Modares University and we thank Dr. Manshadi and Dr. Taghikhani for providing normal samples.

Conflict of interest

No potential conflicts of interest were disclosed.

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Affiliations

  1. Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Jalal Ale Ahmad Highway, Nasr Bridge, P.O.Box 14115-331, Tehran, Iran

    Mohammad Balood, Seyed Alireza Mesbah-Namin & Hamid Zahednasab

  2. Department of Medical Genetics, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran

    Mohammad Hossein Sanati & Mitra Ataei

  3. Sina MS Research Center, Brain and Spinal Injury Research Center, Tehran University of Medical Sciences, Tehran, Iran

    Mohammad Ali Sahraian

Authors
  1. Mohammad Balood
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  2. Seyed Alireza Mesbah-Namin
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  3. Mohammad Hossein Sanati
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  4. Hamid Zahednasab
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  5. Mohammad Ali Sahraian
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  6. Mitra Ataei
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Correspondence to Seyed Alireza Mesbah-Namin.

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Balood, M., Mesbah-Namin, S.A., Sanati, M.H. et al. Inhibitor IκBα promoter functional polymorphisms in patients with multiple sclerosis. Mol Biol Rep 41, 613–616 (2014). https://doi.org/10.1007/s11033-013-2898-3

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  • DOI: https://doi.org/10.1007/s11033-013-2898-3

Keywords

  • IkBα
  • Multiple sclerosis
  • Polymorphism