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MMP-2 −1306C > T polymorphism in breast cancer: a case–control study in a South European population

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Abstract

This case control study aims to investigate the role of MMP-2 −1306C > T polymorphism as a potential risk factor and possible prognostic marker for breast cancer in a South European population. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy controls were recruited. MMP-2 −1306C > T polymorphism was genotyped; multivariate logistic regression as well as Cox regression analysis were performed. MMP-2 −1306C > T status was not associated with breast cancer risk either at the total sample or at the subanalyses on premenopausal and postmenopausal women. At the survival analysis, a trend towards a favorable association between MMP-2 −1306C > T allele and disease-free survival as well as overall survival was observed. Regarding subanalyses on ER-negative and ER-positive cases, the favorable association implicating MMP-2 −1306C > T allele was particularly evident among ER-positive cases; no significant associations emerged among ER-negative cases. MMP-2 −1306C > T polymorphism does not seem to be a risk factor for breast cancer in South European population; however, a trend towards a favorable association with survival has been observed.

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Acknowledgments

A research grant has been received by HeSMO.

Disclosure

“The authors have declared no conflicts of interest”.

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Authors and Affiliations

  1. Department of Clinical Therapeutics, Alexandra Hospital, Medical School, University of Athens, Vas Sofias Ave & Lourou str, 11521, Athens, Greece

    Flora Zagouri, Irene Papaspyrou, Meletios-Athanassios Dimopoulos & Christos A. Papadimitriou

  2. 1st Propaedeutic Surgical Department, Hippocrateio Hospital, University of Athens, Athens, Greece

    Theodoros N. Sergentanis, Dimosthenis Chrysikos, Maria Lymperi & George C. Zografos

  3. Department of Biology, University of Athens, Athens, Greece

    Maria Gazouli

  4. Department of Obstetrics and Gynaecology, Alexandra Hospital, Medical School, University of Athens, Athens, Greece

    Constantine Dimitrakakis, Alexandra Tsigginou & Aris Antsaklis

Authors
  1. Flora Zagouri
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  2. Theodoros N. Sergentanis
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  3. Maria Gazouli
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  4. Constantine Dimitrakakis
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  5. Alexandra Tsigginou
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  6. Irene Papaspyrou
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  7. Dimosthenis Chrysikos
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  8. Maria Lymperi
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  9. George C. Zografos
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  10. Aris Antsaklis
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  11. Meletios-Athanassios Dimopoulos
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  12. Christos A. Papadimitriou
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Corresponding author

Correspondence to Theodoros N. Sergentanis.

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Zagouri, F., Sergentanis, T.N., Gazouli, M. et al. MMP-2 −1306C > T polymorphism in breast cancer: a case–control study in a South European population. Mol Biol Rep 40, 5035–5040 (2013). https://doi.org/10.1007/s11033-013-2604-5

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  • DOI: https://doi.org/10.1007/s11033-013-2604-5

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