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Preeclampsia and ABO blood groups: a systematic review and meta-analysis

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Abstract

Preeclampsia (PE) is a multifactorial pregnancy-specific syndrome which represents one of the leading causes of maternal mortality worldwide. Inherited thrombophilia have been investigated as risk factor for the development of PE and it is currently known that ABO blood group may impact haemostatic balance, having the non-O blood groups (A, B or AB) subjects increased risk for thrombus formation, as compared to those of group O. We performed a systematic review of the literature for published studies investigating whether ABO blood groups could influence PE developing. A sensitive search of four databases identified 45 unique titles. The retrieved papers were assessed independently by authors and a rigorous process of selection and data extract was conduct. Methodological quality of the included studies was also evaluated. Two studies met eligibility criteria. As a main finding of our systematic review, an association between the AB blood group and the occurrence of PE was detected based on two original studies. Considering the role of ABO blood groups on the hemostatic process and thrombus formation, special attention should be given to pregnant patients carrying the AB blood group in order to prevent the syndrome and improve prognosis.

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Acknowledgments

This work received grants from MCT/CT-Saúde and Decit/SCTIE/MS through the National Counsel of Technological, CNPq and FAPEMIG. APSMF, DRGJ, MGC and LMSD are grateful to the National Counsel of Technological and Scientific Development of Brazil (CNPq) for received research fellowship.

Conflict of interest

All authors disclose no financial or personal relationship with other people or organizations that could inappropriately influence their work.

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Authors and Affiliations

  1. Department of Clinical and Toxicological Analyses, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, MG, 31270-901, Brazil

    Patricia Nessralla Alpoim, Melina de Barros Pinheiro, Daniela Rezende Garcia Junqueira, Leticia Gonçalves Freitas, Maria das Graças Carvalho, Ana Paula Salles Moura Fernandes, Flávia Komatsuzaki, Karina Braga Gomes & Luci Maria Sant’Ana Dusse

  2. Centre of Drug Studies (Cemed), Department of Social Pharmacy, School of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil

    Daniela Rezende Garcia Junqueira

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  1. Patricia Nessralla Alpoim
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  2. Melina de Barros Pinheiro
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  3. Daniela Rezende Garcia Junqueira
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  4. Leticia Gonçalves Freitas
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  5. Maria das Graças Carvalho
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  8. Karina Braga Gomes
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  9. Luci Maria Sant’Ana Dusse
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Correspondence to Karina Braga Gomes.

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Alpoim, P.N., de Barros Pinheiro, M., Junqueira, D.R.G. et al. Preeclampsia and ABO blood groups: a systematic review and meta-analysis. Mol Biol Rep 40, 2253–2261 (2013). https://doi.org/10.1007/s11033-012-2288-2

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