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CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis

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Abstract

The aim of this study was to summarize results on the association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) promoter exon-1 +49 and 1722T/C polymorphism with systemic lupus erythematosus (SLE) susceptibility by using the meta-analysis. We searched all the publications about the association between CTLA-4) promoter exon-1 +49 and 1722T/C polymorphism and SLE from PubMed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Previous CTLA-4 association studies with SLE, however, have produced inconsistent results. We have performed a meta-analysis to better assess the purported associations. A total of 17 independent studies (to June 2012) testing association between one or more CTLA-4 polymorphisms and SLE were used in this analysis. We have compared allele and genotype frequencies at two polymorphic sites found in exon-1 (at +49) and the promoter region (at −1722). The data demonstrate that the exon-1 +49 polymorphism is associated with SLE susceptibility in Asian population. The overall risk, measured by odds ratio (OR), stratification by ethnicity indicates the exon-1 +49 GG+GA genotype is associated with SLE, at least in Asians (OR = 0.85, 95 % CI = 0.73–0.99, P = 0.04 for GG+GA vs. AA; OR = 0.85, 95 % CI = 0.72–1.00, P = 0.05 for AG vs. AA). Similar trends are found in allele-specific risk estimates and disease association. Overall, there was significant association between the 1722T/C polymorphism and overall SLE risks (OR = 0.78, 95 % CI = 0.63–0.97, P = 0.04 for GG+GA vs. AA, OR = 0.87, 95 % CI = 0.76–0.99, P = 0.04 for G vs. A) in Asian population.In summary, this meta-analysis demonstrates that the CTLA-4 promoter +49A/G and promoter −1722C/T polymorphism may confer susceptibility to SLE, especially in Asian-derived population.

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Acknowledgments

This work was supported by grant from the National Natural Science Foundation of China (30830089). This work was supported by grants from the Anhui Province universities Key Project of Provincial Natural Science Foundation of China (KJ2008A015).

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Authors and Affiliations

  1. Department of Occupational and Environmental Health, School of Public Health, Anhui Medical University, Hefei, Anhui, China

    Jin-Xia Zhai, Li-Wei Zou, Zhao-Xiang Zhang, Wen-Jing Fan, Han-Yong Wang, Ting Liu, Zheng Ren, Rui-Xue Dai & Dongqing Ye

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  1. Jin-Xia Zhai
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Zhai, JX., Zou, LW., Zhang, ZX. et al. CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Mol Biol Rep 40, 5213–5223 (2013). https://doi.org/10.1007/s11033-012-2125-7

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  • DOI: https://doi.org/10.1007/s11033-012-2125-7

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