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Association of MUC6-minisatellite variants with susceptibility to rectal carcinoma

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Abstract

A secreted MUC6 mucin is reported to be expressed highly in the stomach and gall bladder. In previous our study, the five minisatellites were identified and a significant association between MUC6-MS5 alleles and gastric cancer was reported. Because of aberrant MUC6 expression is often found in gastrointestinal diseases, we evaluated a relationship between MUC6-MS5 and susceptibility to colorectal cancers. Case–control study was performed with 1,103 cancer-free controls and 414 rectal cancer cases. A significant association (OR = 2.70) between short rare MUC6-MS5 alleles (7, 9 repeats) and the occurrence of cancer was observed in rectal cancer [95 % confidence interval (CI), 1.12–6.54; p = 0.022]. Furthermore, a comparison by gender showed the differences in the association ratios between rectal cancer and short rare MUC6-MS5 alleles: male, 3.97 (CI: 1.36–11.5; p = 0.006) versus female 0.91 (CI: 0.18–4.75; p = 0.913). We also examined the association according to lymphovascular invasion (LVI). The frequency of LVI positive rectal cancer was increased in short rare allele cases than in the total rectal cases: 16.2 % versus 42.9 %. Therefore, we suggest that the short rare MUC6-MS5 alleles may be related to cancer development in male and these cancer cases may be related the bad prognosis.

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Acknowledgments

This research was supported by 2011 Collaborative research Program of Nuclear Medical Sciences through the Dongnam Institute of Radiological & Medical Sciences (DIRAMS) funded by the Ministry of Education, Science and Technology (MEST) and Busan Metropolitan city (2011-0593) and by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MEST) (2012-0000481).

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Authors and Affiliations

  1. Department of Biological Science, Dong-A University, 840 Hadan-2-dong, Saha-gu, Busan, 604-714, Korea

    Myoung-Hyun Ahn, Jeong-Ah Kwon, Se-Ra Lee, Si-Hoon Kim, Tae-Hong Kang, Jin Woong Chung & Sun-Hee Leem

  2. Department of Surgery, College of Medicine, Inje University, Busan, 614-735, Korea

    Ki Beom Bae, Tae Doo Jung, Sun Hee Kim, Min Sung An & Kwan Hee Hong

  3. Department of Surgery, College of Medicine, Dong-A University, Busan, 604-714, Korea

    Hong-Jo Choi

  4. Department of Molecular Biology & Immunology, College of Medicine, 34 Amnam-dong, Seo-gu, Busan, 602-703, Korea

    Jeonghoon Heo

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  1. Myoung-Hyun Ahn
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  2. Ki Beom Bae
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  3. Jeong-Ah Kwon
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  12. Tae-Hong Kang
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  13. Jin Woong Chung
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  14. Sun-Hee Leem
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Correspondence to Sun-Hee Leem.

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Ahn, MH., Bae, K.B., Kwon, JA. et al. Association of MUC6-minisatellite variants with susceptibility to rectal carcinoma. Mol Biol Rep 40, 303–308 (2013). https://doi.org/10.1007/s11033-012-2062-5

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  • DOI: https://doi.org/10.1007/s11033-012-2062-5

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