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HTERT MNS16A polymorphism in breast cancer: a case–control study

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Abstract

This case–control study aims to investigate the role of HTERT MNS16A polymorphism as a potential risk factors and/or a prognostic marker for breast cancer. 113 consecutive incident cases of histologically confirmed ductal breast cancer and 124 healthy controls were recruited. HTERT MNS16A polymorphism was genotyped (L: long allele, S: short allele); multivariate logistic regression was performed. No significant association was noted either at the overall analysis (OR = 1.57, 95 % CI 0.84–2.93 for heterozygous LS carriers; OR = 1.02, 95 % CI 0.54–1.95 for homozygous SS carriers) or at the subanalyses in premenopausal and postmenopausal women. With respect to survival analysis, HTERT MNS16A polymorphism was not associated with either disease-free survival or overall survival. HTERT MNS16A polymorphism does not seem to be a risk factor for breast cancer in the Caucasian Greek population. Further, larger studies from other countries and subjects seem to be needed as this novel polymorphism is being examined in depth.

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Acknowledgments

A research grant has been received by HeSMO. FZ: is receiving a research grant from HeSMO.

Conflict of interest

The authors have declared no conflicts of interest.

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Authors and Affiliations

  1. Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece

    Flora Zagouri, Evaggelos Eleutherakis-Papaiakovou, Irene Papaspyrou, Athanassios-Meletios Dimopoulos & Christos A. Papadimitriou

  2. 1st Propaedeutic Surgical Department, Hippocrateio Hospital, University of Athens, 101, Vas Sofias Ave, 11521, Athens, Greece

    Theodoros N. Sergentanis, Dimosthenis Chrysikos, George Theodoropoulos & George C. Zografos

  3. Department of Biology, University of Athens, Athens, Greece

    Maria Gazouli

  4. Department of Obstetrics and Gynaecology, Alexandra Hospital, University of Athens, Athens, Greece

    Alexandra Tsigginou, Constantine Dimitrakakis & Aris Antsaklis

Authors
  1. Flora Zagouri
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  2. Theodoros N. Sergentanis
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  3. Maria Gazouli
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  4. Alexandra Tsigginou
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  5. Constantine Dimitrakakis
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  6. Evaggelos Eleutherakis-Papaiakovou
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  7. Irene Papaspyrou
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  8. Dimosthenis Chrysikos
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  9. George Theodoropoulos
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  10. George C. Zografos
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  11. Aris Antsaklis
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  12. Athanassios-Meletios Dimopoulos
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  13. Christos A. Papadimitriou
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Corresponding author

Correspondence to Theodoros N. Sergentanis.

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Zagouri, F., Sergentanis, T.N., Gazouli, M. et al. HTERT MNS16A polymorphism in breast cancer: a case–control study. Mol Biol Rep 39, 10859–10863 (2012). https://doi.org/10.1007/s11033-012-1982-4

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  • DOI: https://doi.org/10.1007/s11033-012-1982-4

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