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Association of VEGF gene polymorphisms with advanced retinopathy of prematurity: a meta-analysis

Molecular Biology Reports volume 39, pages 10731–10737 (2012)Cite this article

Abstract

Published data on the association of vascular endothelial growth factor (VEGF) gene polymorphisms with retinopathy of prematurity (ROP) are inconclusive. The aim of the study was to assess the association by using meta-analysis. Data were collected from the following electronic databases: PubMed, Elsevier Science Direct, Excerpta Medica Database, Cochrane Library and China National Knowledge Infrastructure, with the last report up to 30 April, 2012. The odds ratio (OR) and its 95 % confidence interval (95 %CI) were used to assess the strength of the association. Meta-analysis was performed in a fixed/random effect model by using the software Review Manager 4.2. A total of 7 studies based on the search criteria were involved in this meta-analysis. Meta-analysis was performed for four VEGF gene polymorphisms (−634G/C, −460T/C, −2578C/A and 936C/T). Significant association was found for −460T/C polymorphism (C vs T: OR = 0.74, 95 %CI = 0.57–0.95, P = 0.02; TC+CC vs TT: OR = 0.75, 95 %CI = 0.47–1.21, P = 0.24; CC vs TT+TC: OR = 0.45, 95 %CI = 0.26–0.76, P = 0.003; CC vs TT: OR = 0.45, 95 %CI = 0.24–0.84, P = 0.01; TC vs TT: OR = 0.96, 95 %CI = 0.59–1.57, P = 0.87) in the VEGF gene, but not for other polymorphisms (−634G/C, −2578C/A and 936C/T). This meta-analysis demonstrates that advanced ROP is associated with VEGF gene −460T/C polymorphism, but not −634G/C, −2578C/A and 936C/T.

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Acknowledgments

We thank all the people who give the help for this study. This work was supported by grants from 2011 Guangdong Province Medical Foundation (A2011550).

Conflict of interest

The authors declare that there is no conflict of interest.

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Affiliations

  1. Department of Pediatrics, Affiliated Shenzhen Maternity & Child Healthcare Hospital of Southern Medical University, Shenzhen, 518028, China

    Peihui Liu, Yawen Li, Chaohui Lian & Yueping Yang

  2. Department of Pediatrics, BaYi Children’s Hospital Affiliated to BaYi Clinical Medical College of Southern Medical University, Peking, 100700, China

    Peihui Liu, Weiqin Zhou & Zhichun Feng

  3. Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, China

    De Wu

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  1. Peihui Liu
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  2. De Wu
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Correspondence to Zhichun Feng.

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Liu, P., Wu, D., Zhou, W. et al. Association of VEGF gene polymorphisms with advanced retinopathy of prematurity: a meta-analysis. Mol Biol Rep 39, 10731–10737 (2012). https://doi.org/10.1007/s11033-012-1964-6

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  • DOI: https://doi.org/10.1007/s11033-012-1964-6

Keywords

  • Retinopathy of prematurity
  • Vascular endothelial growth factor
  • Genetic polymorphisms
  • Meta-analysis