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First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits

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Abstract

Protein JY-1 is a bovine oocyte-specific protein that regulates granulosa cell function and is involved in early embryonic development, influencing the chance of pregnancy. This study investigated molecular markers for the JY-1 gene. Seven SNPs were identified in exon 3 of the gene. The positions of the SNPs in the exon and the respective substitutions are: 163 (T/C), 281 (T/C), 321 (T/C), 532 (T/C), 652 (A/G), 679 (T/C), and 722 (G/C) (GenBank: JN592587 and JF262042.2). SNP 163 is located in a coding region and causes a proline-to-leucine substitution. The other SNPs are located in the 3′UTR region. SNPs 163, 281, 321, and 679 were genotyped in 297 Nellore heifers and the haplotypes were constructed. The haplotypes of JY-1 were not correlated with the traits studied at 5 %.

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Acknowledgments

The authors wish to thank the Fundação de Apoio à Pesquisa do Estado de São Paulo (Fapesp) for the grant of the first author.

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Authors and Affiliations

  1. São Paulo State University, Jaboticabal, Brazil

    Gregório Miguel Ferreira de Camargo, Diercles Francisco Cardoso, Fernanda Maria Monsalves Gil, Patrícia Dias da Silva Fonseca, Larissa Zetouni, Camila Urbano Braz, Ana Claudia de Freitas, Fábio Ricardo Pablos de Souza, Rusbel Raul Aspilcueta-Borquis, Fernando Baldi, Lucia Galvão de Albuquerque & Humberto Tonhati

  2. Brazilian Agricultural Research Corporation (Embrapa), São Carlos, Brazil

    Luciana Correia de Almeida Regitano

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  1. Gregório Miguel Ferreira de Camargo
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  2. Diercles Francisco Cardoso
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  3. Fernanda Maria Monsalves Gil
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  4. Patrícia Dias da Silva Fonseca
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  5. Larissa Zetouni
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  6. Camila Urbano Braz
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  7. Ana Claudia de Freitas
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  8. Fábio Ricardo Pablos de Souza
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  9. Rusbel Raul Aspilcueta-Borquis
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  10. Fernando Baldi
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  11. Lucia Galvão de Albuquerque
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  12. Luciana Correia de Almeida Regitano
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  13. Humberto Tonhati
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Correspondence to Gregório Miguel Ferreira de Camargo.

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de Camargo, G.M.F., Cardoso, D.F., Gil, F.M.M. et al. First polymorphisms in JY-1 gene in cattle (Bos taurus indicus) and their association with sexual precocity and growth traits. Mol Biol Rep 39, 10105–10109 (2012). https://doi.org/10.1007/s11033-012-1884-5

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  • DOI: https://doi.org/10.1007/s11033-012-1884-5

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