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The association between endothelial lipase −384A/C gene polymorphism and acute coronary syndrome in a Chinese population

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Abstract

Endothelial lipase (EL) is a novel member of the triglyceride (TG) lipase family. A growing body of evidence has indicated that EL gene polymorphism might contribute to the process of cardiovascular diseases. This study was aimed to reveal the potential relationship between EL −384A/C gene polymorphism and acute coronary syndrome (ACS) in a Chinese Han population. The subjects were composed of 320 ACS patients and 315 age- and gender- matched controls. We detected the EL −384A/C genotypes and allele frequencies by using polymerase chain reaction-restriction fragment length polymorphism analysis. There was significant difference in AA genotype and AC+CC genotype between ACS and control groups (P = 0.014). The A allele frequency was significantly higher in ACS group than in control group (87.8 vs 83.8 %, P = 0.041). The relationship between the variant and ACS remained significant after adjusting for current smoker, hypertension, diabetes mellitus, total cholesterol and TG (OR = 0.682, 95 % CI = 0.472–0.986). The levels of HDL and ApoA-I were significantly higher in AC+CC genotype than in AA genotype (HDL: 1.20 ± 0.35 vs 1.11 ± 0.29 mmol/L, P = 0.001; ApoA-I: 1.14 ± 0.25 vs 1.08 ± 0.21 g/L, P = 0.009). We found that the EL −384A/C gene polymorphism might be associated with ACS in Chinese Han population, suggesting that the variant might be involved in the pathogenesis of ACS.

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Abbreviations

ACS:

Acute coronary syndrome

CAD:

Coronary artery disease

LDL:

Low density lipoprotein

HDL:

High density lipoprotein

TG:

Triglyceride

LPL:

Lipoprotein lipase

HL:

Hepatic lipase

CVD:

Cardiovascular disease

BP:

Blood pressure

PCR–RFLP:

Polymerase chain reaction–restriction fragment length polymorphism analysis

SPSS:

Statistical package for the social sciences

SNPs:

Single-nucleotide polymorphisms

Apo:

Apolipoprotein

TC:

Total cholesterol

LP(a):

Lipoprotein(a)

AS:

Atherosclerosis

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Acknowledgments

This work was supported by the Science and technology project of Wujin (WS2010010). The authors are grateful to the staff of the department of Cardiology, Wujin Hospital for their facilitation in the sample collection.

Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Cardiology, Wujin Hospital, Affiliated to Jiangsu University, 2 North Yongning Road, Changzhou, Jiangsu Province, People’s Republic of China

    Gaojun Cai, Guoping He & Chuanping Qi

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  1. Gaojun Cai
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  2. Guoping He
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  3. Chuanping Qi
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Correspondence to Gaojun Cai.

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Cai, G., He, G. & Qi, C. The association between endothelial lipase −384A/C gene polymorphism and acute coronary syndrome in a Chinese population. Mol Biol Rep 39, 9879–9884 (2012). https://doi.org/10.1007/s11033-012-1854-y

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  • DOI: https://doi.org/10.1007/s11033-012-1854-y

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