Molecular Biology Reports

, Volume 39, Issue 10, pp 9715–9722 | Cite as

Traditional Chinese medicines benefit to nonalcoholic fatty liver disease: a systematic review and meta-analysis

  • Ke-Qing Shi
  • Yu-Chen Fan
  • Wen-Yue Liu
  • Ling-Fei Li
  • Yong-Ping Chen
  • Ming-Hua ZhengEmail author


Evidences from randomized controlled trials (RCTs) for the efficiency of traditional Chinese medicine (TCM) on the treatment of nonalcoholic fatty liver disease (NAFLD) are conflicting. Here we conducted a systematic review and meta-analysis of RCTs to evaluate the efficiency and safety of TCM in the treatment of NAFLD. Studies were searched on PubMed and China National Knowledge Infrastructure from January 1995 to June 2010. RCTs comparing either TCM formulations alone or in combination with placebo, ursodeoxycholic acid, insulin sensitizers, lipid-lowering drugs, or antioxidants were included. The category of most usually used herbs in the treatment of NAFLD was also calculated. Five thousand nine hundred and four patients from 62 RCTs were included for meta-analysis and 25,661 patients from 419 clinical studies were for TCM formulation analysis. Comparing with western medicines mentioned above, TCM had a better effect on the normalization of alanine aminotransferase and disappearance of radiological steatosis in the treatment of NAFLD. Furthermore, 246 kinds of Chinese herbs were included in our present study, with an average of 10 herbs (range 1–31) in each formulation. Hawthorn Fruit (321 times in 17,670 patients) was the most often used herb in the treatment of NAFLD. In conclusion, TCM is of modest benefit to the treatment of NAFLD.


Herb Fatty liver Therapy Meta-analysis Nonalcoholic fatty liver disease 



Alanine aminotransferase


Confidence interval


Consolidated Standards of Reporting Trials


Nonalcoholic fatty liver disease


Odds ratio


Randomized controlled trial


Traditional Chinese medicine


Ursodeoxycholic acid



This work was supported by grants from National Science and Technology Major Project of China (2012ZX10002004), the Scientific Research Foundation of Wenzhou, Zhejiang Province, China (H20090014, Y20090269), Zhejiang Provincial Administration of Traditional Chinese Medicine (2011ZQ015), Health Bureau of Zhejiang Province (2010KYB070), Research Foundation of Education Bureau of Zhejiang Province (Y201009942) and Project of New Century 551 Talent Nurturing in Wenzhou, Natural Science Foundation of Shandong Province (ZR2010HQ040), Independent Innovation Foundation of Shandong University (IIFSDU, 2010TS013).

Conflict of Interest

All authors have no conflicts of interest.

Supplementary material

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Supplementary Reference 1. References associated with RCTs included in the study. (DOC 36 kb)
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Supplementary Reference 2. References associated with clinical trials summarizing the herbs in TCMs formulations. (DOC 140 kb)
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Supplementary Table 1. Characteristics of included RCTs of TCMs versus placebo for NAFLD (DOC 49 kb)
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Supplementary Table 2. Characteristics of included RCTs of TCMs versus UDCA for NAFLD (DOC 57 kb)
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Supplementary Table 3. Characteristics of included RCTs of TCMs versus insulin sensitizers for NAFLD (DOC 32 kb)
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Supplementary Table 4. Characteristics of included RCTs of TCMs versus fibrates for NAFLD (DOC 52 kb)
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Supplementary Table 5. Characteristics of included RCTs of TCMs versus statins for NAFLD (DOC 65 kb)
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Supplementary Table 6. Characteristics of included RCTs of TCMs versus antioxidants for NAFLD (DOC 62 kb)
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Supplementary material 20 (PDF 61 kb)


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Ke-Qing Shi
    • 1
    • 2
  • Yu-Chen Fan
    • 3
  • Wen-Yue Liu
    • 1
    • 4
  • Ling-Fei Li
    • 1
    • 4
  • Yong-Ping Chen
    • 1
    • 2
  • Ming-Hua Zheng
    • 1
    • 2
    Email author
  1. 1.Department of Infection and Liver DiseasesLiver Research Center, The First Affiliated Hospital of Wenzhou Medical CollegeWenzhouChina
  2. 2.Institute of HepatologyWenzhou Medical CollegeWenzhouChina
  3. 3.Department of HepatologyQilu Hospital of Shandong UniversityJinanChina
  4. 4.School of the First Clinical Medical SciencesWenzhou Medical CollegeWenzhouChina

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