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Association between CTLA-4 exon-1 +49A/G polymorphism and systemic lupus erythematosus: an updated analysis

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Abstract

The results of studies on association between CTLA-4 exon-1 +49A/G (rs231775) polymorphism and susceptibility to systemic lupus erythematosus are controversial. To derive a more precise estimation of the relationship between the CTLA-4 exon-1 +49A/G polymorphism and SLE, a meta-analysis of 18 published case–control studies was performed. 18 studies meeting our inclusion criteria comprising 1806 SLE cases and 2,490 controls were included. The effect summary odds ratio (OR) and 95 % confidence intervals were obtained. Publication bias was tested by funnel plot, Egger’s test and heterogeneity was assessed. The combined results showed that there were significant differences in genotype distribution between SLE cases and control on the basis of all studies, GG versus AA (OR = 1.53, 95 % CI: 1.12–2.10), GG versus GA/AA (OR = 1.30, 95 % CI: 1.04–1.64), GG versus GA (OR = 1.27, 95 % CI: 1.03–1.55). When stratifying for the race, the phenomenon was found that SLE cases had a significantly higher frequency of GG/GA versus AA (OR = 1.58, 95 % CI: 1.23–2.03), GG versus AA (OR = 1.89, 95 % CI: 1.23–2.91), GG versus GA/AA(OR = 1.39, 95 % CI: 1.03–1.89), GA versus AA(OR = 1.38, 95 % CI: 1.06–1.80) and G versus A(OR = 1.34, 95 % CI: 1.07–1.67) than control in Asians. Our meta-analysis results suggest that CTLA-4 exon-1 +49A/G polymorphism might be a risk factor for SLE susceptibility, at least in Asians. The large sample and well-designed study based on different ethnic groups should be considered in future associated studies to clarify the association of CTLA-4 exon-1 +49A/G polymorphism with SLE susceptibility.

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Acknowledgments

The authors wish to thank all families for participating in this study. And we thank editors of Molecular Biology Reports for editing the manuscript.

Conflict of interest

No conflict of interest had been declared by the authors.

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Authors and Affiliations

  1. Department of Preventive Medicine, Wannan Medical College, Wuhu, 241002, Anhui, China

    Wei-wei Chang & Ying-shui Yao

  2. Department of hospital infection management office, Wuhu Hospital of traditional Chinese Medicine, Wuhu, 241000, Anhui, China

    Liu Zhang

  3. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, 230032, Anhui, China

    Hong Su

Authors
  1. Wei-wei Chang
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  2. Liu Zhang
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  3. Ying-shui Yao
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  4. Hong Su
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Corresponding author

Correspondence to Ying-shui Yao.

Additional information

Wei-wei Chang and Liu Zhang contributed equally to this work and should be considered as co-first authors.

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Chang, Ww., Zhang, L., Yao, Ys. et al. Association between CTLA-4 exon-1 +49A/G polymorphism and systemic lupus erythematosus: an updated analysis. Mol Biol Rep 39, 9159–9165 (2012). https://doi.org/10.1007/s11033-012-1788-4

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  • DOI: https://doi.org/10.1007/s11033-012-1788-4

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