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NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis

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Abstract

Published data have implicated NAT2 polymorphisms as risk factors for various cancers. A number of studies have focused on the association of NAT2 polymorphisms with susceptibility to oral carcinoma and have yielded inconclusive results. The aim of the present study was to derive a more precise estimation of the relationship. We first carried out a deliberate search in the databases without a language limitation, covering all papers published up to Dec 2011. A total of seven case–control studies including 1,379 cases and 1,868 controls were selected and the relevant data were extracted for systematic meta-analyses. No significant association was found for the overall data (OR: 1.04, 95 % CI: 0.79–1.39). In subgroup analyses according to ethnicity, slow acetylators might increase oral cancer risk among Asians (OR: 1.38, 95 % CI: 1.04–1.82) but not Caucasians or Mixed races. The data suggested that NAT2 polymorphisms might be a low-penetrant risk factor for oral carcinoma in Asians.

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References

  1. Zygogianni AG, Kyrgias G, Karakitsos P, Psyrri A, Kouvaris J et al (2011) Oral squamous cell cancer: early detection and the role of alcohol and smoking. Head Neck Oncol 3:2

    Article  PubMed  PubMed Central  Google Scholar 

  2. Reichart PA, Nguyen XH (2008) Betel quid chewing, oral cancer and other oral mucosal diseases in Vietnam: a review. J Oral Pathol Med 37:511–514

    Article  CAS  PubMed  Google Scholar 

  3. Boffetta P (2010) Biomarkers in cancer epidemiology: an integrative approach. Carcinogenesis 31:121–126

    Article  CAS  PubMed  Google Scholar 

  4. Klaunig JE, Kamendulis LM, Hocevar BA (2010) Oxidative stress and oxidative damage in carcinogenesis. Toxicol Pathol 38:96–109

    Article  CAS  PubMed  Google Scholar 

  5. Zhuo WL, Zhang YS, Wang Y, Zhuo XL, Zhu B et al (2009) Association studies of CYP1A1 and GSTM1 polymorphisms with esophageal cancer risk: evidence-based meta-analyses. Arch Med Res 40:169–179

    Article  CAS  PubMed  Google Scholar 

  6. Liu L, Wagner CR, Hanna PE (2009) Isoform-selective inactivation of human arylamine N-acetyltransferases by reactive metabolites of carcinogenic arylamines. Chem Res Toxicol 22:1962–1974

    Article  CAS  PubMed  Google Scholar 

  7. Garcia-Martin E (2008) Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr Drug Metab 9:487–497

    Article  CAS  PubMed  Google Scholar 

  8. Agundez JA (2008) Polymorphisms of human N-acetyltransferases and cancer risk. Curr Drug Metab 9:520–531

    Article  CAS  PubMed  Google Scholar 

  9. Luck H, Kinzig M, Jetter A, Fuhr U, Sorgel F (2009) Mesalazine pharmacokinetics and NAT2 phenotype. Eur J Clin Pharmacol 65:47–54

    Article  PubMed  Google Scholar 

  10. Sabbagh A, Darlu P, Crouau-Roy B, Poloni ES (2011) Arylamine N-acetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. PLoS One 6:e18507

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Munafo MR, Clark TG, Flint J (2004) Assessing publication bias in genetic association studies: evidence from a recent meta-analysis. Psychiatry Res 129:39–44

    Article  PubMed  Google Scholar 

  12. Egger M, Davey Smith G, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. Br Med J 315:629–634

    Article  CAS  Google Scholar 

  13. Hou YY, Ou HL, Chu ST, Wu PC, Lu PJ et al (2011) NAT2 slow acetylation haplotypes are associated with the increased risk of betel quid-related oral and pharyngeal squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112:484–492

    Article  PubMed  Google Scholar 

  14. Jourenkova-Mironova N, Wikman H, Bouchardy C, Mitrunen K, Dayer P et al (1999) Role of arylamine N-acetyltransferase 1 and 2 (NAT1 and NAT2) genotypes in susceptibility to oral/pharyngeal and laryngeal cancers. Pharmacogenetics 9:533–537

    CAS  PubMed  Google Scholar 

  15. Morita S, Yano M, Tsujinaka T, Akiyama Y, Taniguchi M et al (1999) Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to head-and-neck squamous-cell carcinoma. Int J Cancer 80:685–688

    Article  CAS  PubMed  Google Scholar 

  16. Buch SC, Nazar-Stewart V, Weissfeld JL, Romkes M (2008) Case–control study of oral and oropharyngeal cancer in whites and genetic variation in eight metabolic enzymes. Head Neck 30:1139–1147

    Article  PubMed  PubMed Central  Google Scholar 

  17. Chen C, Ricks S, Doody DR, Fitzgibbons ED, Porter PL et al (2001) N-acetyltransferase 2 polymorphisms, cigarette smoking and alcohol consumption, and oral squamous cell cancer risk. Carcinogenesis 22:1993–1999

    Article  CAS  PubMed  Google Scholar 

  18. Hahn M, Hagedorn G, Kuhlisch E, Schackert HK, Eckelt U (2002) Genetic polymorphisms of drug-metabolizing enzymes and susceptibility to oral cavity cancer. Oral Oncol 38:486–490

    Article  CAS  PubMed  Google Scholar 

  19. Katoh T, Kaneko S, Boissy R, Watson M, Ikemura K et al (1998) A pilot study testing the association between N-acetyltransferases 1 and 2 and risk of oral squamous cell carcinoma in Japanese people. Carcinogenesis 19:1803–1807

    Article  CAS  PubMed  Google Scholar 

  20. Majumder M, Sikdar N, Ghosh S, Roy B (2007) Polymorphisms at XPD and XRCC1 DNA repair loci and increased risk of oral leukoplakia and cancer among NAT2 slow acetylators. Int J Cancer 120:2148–2156

    Article  CAS  PubMed  Google Scholar 

  21. Marques CF, Koifman S, Koifman RJ, Boffetta P, Brennan P et al (2006) Influence of CYP1A1, CYP2E1, GSTM3 and NAT2 genetic polymorphisms in oral cancer susceptibility: results from a case–control study in Rio de Janeiro. Oral Oncol 42:632–637

    Article  CAS  PubMed  Google Scholar 

  22. Balaji L, Krishna BS, L VKSB (2011) An unlikely role for the NAT2 genotypes and haplotypes in the oral cancer of South Indians. Arch Oral Biol. doi:10.1016/j.archoralbio.2011.10.019

  23. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. Br Med J 327:557–560

    Article  Google Scholar 

  24. Tobias A (1999) Assessing the influence of a single study in the meta-analysis estimate. Stata Techn Bull 8:15–17

    Google Scholar 

  25. Gong C, Hu X, Gao Y, Cao Y, Gao F et al (2011) A meta-analysis of the NAT1 and NAT2 polymorphisms and prostate cancer: a huge review. Med Oncol 28:365–376

    Article  CAS  PubMed  Google Scholar 

  26. Ying XJ, Dong P, Shen B, Wang J, Wang S et al (2011) Possible association of NAT2 polymorphism with laryngeal cancer risk: an evidence-based meta-analysis. J Cancer Res Clin Oncol 137:1661–1667

    Article  CAS  PubMed  Google Scholar 

  27. Garcia-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M et al (2005) NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 366:649–659

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Moore LE, Baris DR, Figueroa JD, Garcia-Closas M, Karagas MR et al (2011) GSTM1 null and NAT2 slow acetylation genotypes, smoking intensity and bladder cancer risk: results from the New England bladder cancer study and NAT2 meta-analysis. Carcinogenesis 32:182–189

    Article  CAS  PubMed  Google Scholar 

  29. Ochs-Balcom HM, Wiesner G, Elston RC (2007) A meta-analysis of the association of N-acetyltransferase 2 gene (NAT2) variants with breast cancer. Am J Epidemiol 166:246–254

    Article  PubMed  Google Scholar 

  30. Zhang J, Qiu LX, Wang ZH, Wang JL, He SS et al (2010) NAT2 polymorphisms combining with smoking associated with breast cancer susceptibility: a meta-analysis. Breast Cancer Res Treat 123:877–883

    Article  PubMed  Google Scholar 

  31. Cui D, Wang Z, Zhao E, Ma J, Lu W (2011) NAT2 polymorphism and lung cancer risk: a meta-analysis. Lung Cancer 73:153–157

    Article  PubMed  Google Scholar 

  32. Zhong X, Hui C, Xiao-Ling W, Yan L, Na L (2010) NAT2 polymorphism and gastric cancer susceptibility: a meta-analysis. Arch Med Res 41:275–280

    Article  PubMed  Google Scholar 

  33. Brockton N, Little J, Sharp L, Cotton SC (2000) N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol 151:846–861

    Article  CAS  PubMed  Google Scholar 

  34. Walker K, Ginsberg G, Hattis D, Johns DO, Guyton KZ et al (2009) Genetic polymorphism in N-acetyltransferase (NAT): population distribution of NAT1 and NAT2 activity. J Toxicol Environ Health B Crit Rev 12:440–472

    Article  CAS  PubMed  Google Scholar 

  35. de Lima KW, Guembarovski RL, Oda JM, Ramos G, Oliveira BV et al (2011) Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals. Clin Exp Med. doi:10.1007/s10238-011-0140-y

    PubMed  Google Scholar 

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Acknowledgments

This work was supported by Initial Fund for Doctors of Guiyang Medical College (2009–14) and China Postdoctoral Science Foundation (20100471772).

Conflict of interest

None declared.

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Authors and Affiliations

  1. Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China

    Xian-Lu Zhuo, Yan Zhou & Ying-Hui Tan

  2. Affiliated Hospital of Guiyang Medical College, Guiyang, 550004, China

    Xian-Lu Zhuo, Hou-Yu Zhao & Yu-Feng Song

  3. Department of Otolaryngology, Southwest Hospital, Third Military Medical University, Chongqing, China

    Jun-Jun Ling

Authors
  1. Xian-Lu Zhuo
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  2. Jun-Jun Ling
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  3. Yan Zhou
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Corresponding authors

Correspondence to Yu-Feng Song or Ying-Hui Tan.

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Zhuo, XL., Ling, JJ., Zhou, Y. et al. NAT2 polymorphisms with oral carcinoma susceptibility: a meta-analysis. Mol Biol Rep 39, 8813–8819 (2012). https://doi.org/10.1007/s11033-012-1744-3

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  • DOI: https://doi.org/10.1007/s11033-012-1744-3

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