Association of the IL-10 polymorphisms and periodontitis: a meta-analysis
- 634 Downloads
No clear consensus has been reached regarding the association of IL-10 polymorphisms and periodontitis. Therefore, we performed a meta-analysis of case–control studies and a systemic review in an effort to systematically summarize the existing knowledge. Studies were identified by searching PubMed database until December 2011. IL-10 −1082 (−1087) A>G, −819 (−824) C>T and −592 (−597) C>A polymorphisms were included in the present meta-analysis. We calculated the specific odds ratios along with their 95 % confidence intervals to compare the distribution of alleles and genotypes between cases and controls. An additive “per-allele” model (major allele vs. minor allele) was performed, and dominant and recessive models were also considered. The random-effects model was applied for the analysis. Cumulative analysis was also performed. Heterogeneity and publication bias were assessed. Nine case–control studies involving 841 periodontitis cases (644 chronic periodontitis and 197 aggressive periodontitis cases) and 748 controls were included. We found statistically significant association of IL-10 −819 (−824) C>T and IL-10 −592 (−597) C>A polymorphisms in Caucasians. The IL-10 −819 (−824) T and −592 (−597) A alleles may confer a relative increase in the risk for chronic periodontitis in Caucasians. Future studies may be important to reinforce these findings.
KeywordsInterleukin-10 Meta-analysis Periodontitis Polymorphism
This work was partially supported by the PhD grant SFRH/BD/44490/2008 of the Science and Technology Foundation (FCT) from Portugal.
- 2.Papapanou RN, Lindhe J (2003) Epidemiology of periodontal diseases. In: Lindhe J, Karring T, Lang NP (eds) Clinical periodontology and implant dentistry, 4th edn. Blackwell, Oxford, pp 50–80Google Scholar
- 36.Claudino M, Trombone APF, Cardoso CR, Ferreira SB Jr, Martins W Jr, Assis GF, Santos CF, Trevilatto PC, Campanelli AP, Silva JS, Garlet GP (2008) The broad effects of the functional IL-10 promoter −592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. J Leukoc Biol 84:1565–1573PubMedCrossRefGoogle Scholar
- 38.Hu K-F, Huang K-C, Ho Y-P, Lin Y-C, Ho K-Y, Wu Y-M, Yang Y-H, Tsai C-C (2009) Interleukin-10 (−592 C/A) and interleukin-12B (+16974 A/C) gene polymorphisms and the interleukin-10 ATA haplotype are associated with periodontitis in a Taiwanese population. J Periodontal Res 44:378–385PubMedCrossRefGoogle Scholar
- 48.Haverkamp MH, Lindeboom JA, de Visser AW, Kremer D, Kuijpers TW, van de Vosse E, van Dissel JT (2010) Nontuberculous mycobacterial cervicofacial lymphadenitis in children from the multicenter, randomized, controlled trial in The Netherlands: relevance of polymorphisms in candidate host immunity genes. Int J Pediatr Otorhinolaryngol 74(7):752–754PubMedCrossRefGoogle Scholar
- 50.Larsson L, Thorbert-Mros S, Rymo L, Berglungh T (2011) Interleukin-10 (Il-10) genotypes of the −1087 single nucleotide polymorphism influence Sp1 expression in periodontitis lesions. J Periodontol. doi: 10.1902/jop.2011.100623
- 52.Crawley E, Kay R, Sillibourne J, Patel P, Hutchinson I, Woo P (1999) Polymorphic haplotypes of the interleukin-10 5′ flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. Arthritis Rheum 42:1101–1108PubMedCrossRefGoogle Scholar