Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: a meta-analysis

Abstract

The aim of this study was to explore whether vitamin D receptor (VDR) polymorphisms confer susceptibility to psoriasis. Meta-analyses were conducted on the associations between the VDR ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis. Nine relevant studies on VDR polymorphisms and psoriasis were included in this meta-analysis, which involved 742 psoriasis patients and 715 controls. Meta-analysis indicated an association between the VDR ApaI A allele and psoriasis in Turkish studies (OR = 0.684, 95% CI = 0.475–0.985, p = 0.041). Meta-analysis indicated an association between the BsmI B allele and psoriasis in Asians (OR = 0.636, 95% CI = 0.411–0.984, p = 0.041), and showed a significant association between the FF and ff genotypes of the FokI polymorphism and psoriasis in all study subjects and in Turkish studies (OR = 2.028, 95% CI = 1.194–3.446, p = 0.009; OR = 3.582, 95% CI = 1.602–8.009, p = 0.002). This meta-analysis suggests that the VDR ApaI polymorphism confers susceptibility to psoriasis in the Turkish population. In addition, associations were found between the BsmI polymorphism and susceptibility to psoriasis in Asians and between the Fok I polymorphism and psoriasis in the Turkish population.

This is a preview of subscription content, access via your institution.

Fig. 1
Fig. 2

References

  1. 1.

    Bhalerao J, Bowcock AM (1998) The genetics of psoriasis: a complex disorder of the skin and immune system. Hum Mol Genet 7:1537–1545

    PubMed  Article  CAS  Google Scholar 

  2. 2.

    Lee KH, Son MK, Ha YJ, Choi ST, Lee SW, Park YB et al (2010) Inflammatory polyarthritis in a patient with psoriasis: is it psoriatic arthritis or rheumatoid arthritis? Korean J Intern Med 25:224–226

    PubMed  Article  Google Scholar 

  3. 3.

    Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NV, Jenisch S et al (2006) Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet 78:827–851

    PubMed  Article  CAS  Google Scholar 

  4. 4.

    Zhang XJ, Huang W, Yang S, Sun LD, Zhang FY, Zhu QX et al (2009) Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21. Nat Genet 41:205–210

    PubMed  Article  CAS  Google Scholar 

  5. 5.

    Maruotti N, Cantatore FP (2010) Vitamin D and the immune system. J Rheumatol 37:491–495

    PubMed  Article  CAS  Google Scholar 

  6. 6.

    Boonstra A, Barrat FJ, Crain C, Heath VL, Savelkoul HF, O’Garra A (2001) 1alpha, 25-dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol 167:4974–4980

    PubMed  CAS  Google Scholar 

  7. 7.

    Koizumi T, Nakao Y, Matsui T, Nakagawa T, Matsuda S, Komoriya K et al (1985) Effects of corticosteroid and 1,24R-dihydroxy-vitamin D3 administration on lymphoproliferation and autoimmune disease in MRL/MP-lpr/lpr mice. Int Arch Allergy Appl Immunol 77:396–404

    PubMed  Article  CAS  Google Scholar 

  8. 8.

    Miyamoto K, Kesterson RA, Yamamoto H, Taketani Y, Nishiwaki E, Tatsumi S et al (1997) Structural organization of the human vitamin D receptor chromosomal gene and its promoter. Mol Endocrinol 11:1165–1179

    PubMed  Article  CAS  Google Scholar 

  9. 9.

    Morrison NA, Yeoman R, Kelly PJ, Eisman JA (1992) Contribution of trans-acting factor alleles to normal physiological variability: vitamin D receptor gene polymorphism and circulating osteocalcin. Proc Natl Acad Sci USA 89:6665–6669

    PubMed  Article  CAS  Google Scholar 

  10. 10.

    Uitterlinden AG, Fang Y, Van Meurs JB, Pols HA, Van Leeuwen JP (2004) Genetics and biology of vitamin D receptor polymorphisms. Gene 338:143–156

    PubMed  Article  CAS  Google Scholar 

  11. 11.

    Uitterlinden AG, Fang Y, van Meurs JB, van Leeuwen H, Pols HA (2004) Vitamin D receptor gene polymorphisms in relation to Vitamin D related disease states. J Steroid Biochem Mol Biol 89–90:187–193

    PubMed  Article  Google Scholar 

  12. 12.

    Egger M (1997) Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ 315:629–634

    PubMed  Article  CAS  Google Scholar 

  13. 13.

    Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21:1539–1558

    PubMed  Article  Google Scholar 

  14. 14.

    Egger M, Smith GD, Phillips AN (1997) Meta-analysis: principles and procedures. BMJ 315:1533–1537

    PubMed  Article  CAS  Google Scholar 

  15. 15.

    DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177–188

    PubMed  Article  CAS  Google Scholar 

  16. 16.

    Zuel-Fakkar NM, Kamel MM, Asaad MK, Mahran MZ, Shehab AA (2011) A study of ApaI and TaqI genotypes of the vitamin D receptor in Egyptian patients with psoriasis. Clin Exp Dermatol 36:355–359

    PubMed  Article  CAS  Google Scholar 

  17. 17.

    Dayangac-Erden D, Karaduman A, Erdem-Yurter H (2007) Polymorphisms of vitamin D receptor gene in Turkish familial psoriasis patients. Arch Dermatol Res 299:487–491

    PubMed  Article  CAS  Google Scholar 

  18. 18.

    Halsall JA, Osborne JE, Pringle JH, Hutchinson PE (2005) Vitamin D receptor gene polymorphisms, particularly the novel A-1012G promoter polymorphism, are associated with vitamin D3 responsiveness and non-familial susceptibility in psoriasis. Pharmacogenet Genomics 15:349–355

    PubMed  Article  CAS  Google Scholar 

  19. 19.

    Ruggiero M, Gulisano M, Peruzzi B, Giomi B, Caproni M, Fabbri P et al (2004) Vitamin D receptor gene polymorphism is not associated with psoriasis in the Italian Caucasian population. J Dermatol Sci 35:68–70

    PubMed  Article  CAS  Google Scholar 

  20. 20.

    Saeki H, Asano N, Tsunemi Y, Takekoshi T, Kishimoto M, Mitsui H et al (2002) Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris. J Dermatol Sci 30:167–171

    PubMed  Article  CAS  Google Scholar 

  21. 21.

    Kaya TI, Erdal ME, Tursen U, Camdeviren H, Gunduz O, Soylemez F et al (2002) Association between vitamin D receptor gene polymorphism and psoriasis among the Turkish population. Arch Dermatol Res 294:286–289

    PubMed  CAS  Google Scholar 

  22. 22.

    Okita H, Ohtsuka T, Yamakage A, Yamazaki S (2002) Polymorphism of the vitamin D(3) receptor in patients with psoriasis. Arch Dermatol Res 294:159–162

    PubMed  Article  CAS  Google Scholar 

  23. 23.

    Lee DY, Park BS, Choi KH, Jeon JH, Cho KH, Song KY et al (2002) Vitamin D receptor genotypes are not associated with clinical response to calcipotriol in Korean psoriasis patients. Arch Dermatol Res 294:1–5

    PubMed  Article  CAS  Google Scholar 

  24. 24.

    Park BS, Park JS, Lee DY, Youn JI, Kim IG (1999) Vitamin D receptor polymorphism is associated with psoriasis. J Invest Dermatol 112:113–116

    PubMed  Article  CAS  Google Scholar 

  25. 25.

    Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177–182

    PubMed  Article  CAS  Google Scholar 

  26. 26.

    Lee YH, Rho YH, Choi SJ, Ji JD, Song GG, Nath SK et al (2007) The PTPN22 C1858T functional polymorphism and autoimmune diseases–a meta-analysis. Rheumatology (Oxford) 46:49–56

    Article  CAS  Google Scholar 

  27. 27.

    Lee YH, Harley JB, Nath SK (2006) Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet 14:364–371

    PubMed  Article  CAS  Google Scholar 

  28. 28.

    Crispin JC, Liossis SN, Kis-Toth K, Lieberman LA, Kyttaris VC, Juang YT et al (2010) Pathogenesis of human systemic lupus erythematosus: recent advances. Trends Mol Med 16:47–57

    PubMed  Article  CAS  Google Scholar 

  29. 29.

    Raychaudhuri S (2010) Recent advances in the genetics of rheumatoid arthritis. Curr Opin Rheumatol 22:109–118

    PubMed  Article  CAS  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Young Ho Lee.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lee, Y.H., Choi, S.J., Ji, J.D. et al. Vitamin D receptor ApaI, TaqI, BsmI, and FokI polymorphisms and psoriasis susceptibility: a meta-analysis. Mol Biol Rep 39, 6471–6478 (2012). https://doi.org/10.1007/s11033-012-1466-6

Download citation

Keywords

  • Psoriasis
  • Vitamin D receptor
  • Polymorphism
  • Meta-analysis