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Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population

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Abstract

Several studies focused on investigating genetic polymorphisms in order to estimate genetic contribution to lung cancer often showed conflicting results. In this study, we investigated the role of GSTM1, GSTT1, GSTP1 exon 5 and exon 6 polymorphisms on developing lung cancer and histological subtypes in 213 lung cancer patients and 231 controls. GSTM1 null, GSTT1 null, and GSTP1 exon 5 variant genotypes did not show a significant risk for developing lung cancer overall. Significant association was noted between GSTP1 exon 6 variant genotypes and overall lung cancer risk (OR 2.17, 95% CI 1.25–3.78; P = 0.006). These results show that GSTP1 exon 6 polymorphism might be an important factor in determining lung cancer susceptibility in a Turkish population.

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Acknowledgment

This research was supported by the Research Fund of Ankara University. Project number: 2006-08-03-002HPD.

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  1. Meral Gulhan

    Present address: Department of Chest Diseases, Ridvan Ege Hospital, Ufuk University, Ankara, Turkey

Authors and Affiliations

  1. Department of Toxicology, Faculty of Pharmacy, Ankara University, Tandoğan, 06100, Ankara, Turkey

    Ahmet O. Ada, Figen Hancer, Emre Soydas & Mumtaz Iscan

  2. Department of Pharmacology, Faculty of Medicine, University of Giresun, Giresun, Turkey

    Semih C. Kunak

  3. Atatürk Pulmonary Diseases and Thoracic Surgery Hospital, Sanatoryum, Ankara, Turkey

    Sibel Alpar & Meral Gulhan

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  1. Ahmet O. Ada
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Ada, A.O., Kunak, S.C., Hancer, F. et al. Association between GSTM1, GSTT1, and GSTP1 polymorphisms and lung cancer risk in a Turkish population. Mol Biol Rep 39, 5985–5993 (2012). https://doi.org/10.1007/s11033-011-1411-0

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