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Polymorphisms of the Interferon gamma gene and coronary artery disease in the Korean population

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Abstract

Abundant evidence supports the hypothesis that inflammation plays an important role in the development of coronary artery disease (CAD). In this study, we investigated whether genetic polymorphisms of the Interferon gamma (IFNG) gene were associated with the number of diseased vessels in CAD patients in the Korean population. To observe the association between the IFNG gene and the number of diseased vessels, we genotyped 635 CAD patients for a single nucleotide polymorphism (SNP, rs2430561) and a microsatellite (CAn repeats, rs3138557) located in the first intron of the IFNG gene using the direct sequencing and gene scan method. The number of microsatellites was increased in the one- and two-vessel disease groups. A combined analysis of the genotype of rs2430561 and the number of microsatellites revealed that the number of diseased vessels was associated with CA12-TT and CA13-TT. Our results suggest that the IFNG gene may be one of the factors determining the extent of CAD in the Korean population. Larger collaborative studies are needed to confirm these results.

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Acknowledgments

This research was supported by the Kyung Hee University Research Fund in 2008 (KHU-20081264).

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Authors and Affiliations

  1. Soonchunhyang Medical Research Institute, College of Medicine, Soonchunhyang University, Chunan, 330-090, Republic of Korea

    Hak-Jae Kim

  2. Kohwang Medical Research Institute, School of Medicine, Kyung Hee University, Seoul, 130-701, Republic of Korea

    Sung Wook Kang & Joo-Ho Chung

  3. Department of Cardiology, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

    Soo-Joong Kim

  4. Department of Preventive Medicine, School of Medicine, Kyung Hee University, Seoul, Republic of Korea

    Bong-Keun Choe

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  1. Hak-Jae Kim
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  2. Sung Wook Kang
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Correspondence to Soo-Joong Kim or Bong-Keun Choe.

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Kim, HJ., Kang, S.W., Chung, JH. et al. Polymorphisms of the Interferon gamma gene and coronary artery disease in the Korean population. Mol Biol Rep 39, 5425–5432 (2012). https://doi.org/10.1007/s11033-011-1342-9

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  • DOI: https://doi.org/10.1007/s11033-011-1342-9

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