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Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population

Molecular Biology Reports volume 39, pages 1427–1433 (2012)Cite this article

Abstract

Chronic obstructive pulmonary disease (COPD) is a complex human disease influenced by multiple genes and environmental factors. The SERPINE2 gene has recently been demonstrated to be associated with COPD onset in a non-East Asian population. In this study, we genotyped 20 single nucleotide polymorphisms (SNPs) in SERPINE2 from 310 cases and 203 controls, all of which belong to the Han from North China. Genotype frequencies were compared between the cases and the controls and analyzed for statistical significance. Two SNPs (rs729631 and rs975278), which are in strong linkage disequilibrium (LD) and locate in block 1 on the LD map of our samples, showed significant association both with the risk of COPD and decline in baseline lung function after Bonferroni correction (P < 0.05). This study provides further evidences for SERPINE2 gene as a COPD susceptible gene, and block 1 of SERPINE2 appears to be the genetic variant region that affects the Han Chinese.

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Acknowledgments

This study is supported by the Beijing Science and Technology Projects (Z090507006209018) and New Star Program of Beijing Science and Technology (2009A11). We thank Liming Zhang, Baosen Pang, and Feng Zhang for coordinating the subject’s enrollment and molecular genetic studies. We also appreciated Dr. Dahai Yu and Weili Zhang’s comments for the manuscript. The authors thank all investigators in each center for their contributions to this study.

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Affiliations

  1. Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders, Beijing Institute of Respiratory Medicine, Department of Respiratory and Critical Care Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No 8, Gongren Tiyuchang Nanlu, Chao-yang District, Beijing, 100020, China

    Li An, Ting Yang, Yingxiang Lin, Hong Zhang, Xia Jiao, Huaping Dai & Chen Wang

  2. CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, No 7, Beitucheng West Road, Chaoyang District, Beijing, 100029, China

    Yongbiao Zhang

  3. Biomedical Engineering Institute of Capital Medical University, Capital Medical University, No 10, Xitoutiao, You An Men, Beijing, 100069, China

    Lin Hua

  4. Beijing Hospital, Ministry of Health, No 8, Gongren Tiyuchang Nanlu, Chao-yang District, Beijing, 100020, China

    Chen Wang

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  1. Li An
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  2. Ting Yang
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  3. Yongbiao Zhang
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  4. Yingxiang Lin
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  5. Hong Zhang
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  6. Xia Jiao
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  7. Lin Hua
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  8. Huaping Dai
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  9. Chen Wang
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Correspondence to Chen Wang.

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An, L., Yang, T., Zhang, Y. et al. Association of SERPINE2 gene with the risk of chronic obstructive pulmonary disease and spirometric phenotypes in northern Han Chinese population. Mol Biol Rep 39, 1427–1433 (2012). https://doi.org/10.1007/s11033-011-0877-0

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  • DOI: https://doi.org/10.1007/s11033-011-0877-0

Keywords

  • Chronic obstructive pulmonary disease
  • Pulmonary function
  • SERPINE2
  • Genetics
  • Association