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Molecular Biology Reports

, Volume 38, Issue 5, pp 2895–2901 | Cite as

Sterol regulatory element-binding transcription factor (SREBF)-2, SREBF cleavage-activating protein (SCAP), and premature coronary artery disease in a Chinese population

  • Zhong ChenEmail author
  • Zhen Ding
  • Genshan Ma
  • Naifeng Liu
  • Qi Qian
Article

Abstract

Cellular cholesterol homeostasis is controlled by the sterol-regulatory element binding transcription factors (SREBFs) that are activated by an SREBF cleavage-activating protein (SCAP). SREBF-2 1784G > C single nucleotide polymorphism (SNP, rs2228314) and SCAP 2386A > G variant (rs12487736) are associated with early onset myocardial infarction (MI) and sudden cardiac death in middle-aged men. We investigated whether these two SNPs are determinants of premature coronary artery disease (CAD) in a Chinese population. We studied 431 consecutive patients, including 197 with coronary stenosis ≥50% or previous MI and 234 controls without documented CAD (males <55 years and females <65 years). All subjects were genotyped for two SNPs by using the ligase detection reaction method. The three genotypes GG, GC, and CC were present in rs2228314 and two genotypes AA and AG in rs12487736. No gender-specific differences were found in genotype distribution and allele frequencies of these two SNPs between patients with and without CAD. The biochemical and clinical risk factors among participants were not influenced by variants at rs2228314. Logistic regression did not detect the association of these two SNPs with premature CAD, nor did there exist any association of these two SNPs among groups of patients with 0, 1, 2, and 3-vessel disease (all P > 0.05). We could not identify any association between these two SNPs and premature CAD or extent of coronary lesions in a Chinese population.

Keywords

Atherosclerosis Coronary artery disease Premature Genetics Polymorphism Single nucleotide Metabolism 

Notes

Acknowledgements

This study was supported partially by grants from the Nanjing Scientific Development Project (2006ZD016).

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Zhong Chen
    • 1
    Email author
  • Zhen Ding
    • 1
  • Genshan Ma
    • 1
  • Naifeng Liu
    • 1
  • Qi Qian
    • 1
  1. 1.Department of Cardiology, The Affiliated ZhongDa Hospital and Institute of Cardiovascular DiseaseSoutheast UniversityNanjingPeople’s Republic of China

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