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Developmental expression changes of the genes involved in IGFI signaling pathway in longissimus dorsi muscle of Tongcheng and Yorkshire pigs during postnatal growth

Molecular Biology Reports volume 38, pages 5133–5138 (2011)Cite this article

Abstract

IGFI signaling pathway is sufficient to regulate myofibre hypertrophy postnatally, which is associated with muscle mass in economically livestock. In the present study, we drafted the developmental expression pattern of eight genes implicated in IGFI system across six stages of postnatal myofibre growth in Yorkshire and Tongcheng pigs. The results indicated that GRB2 may contribute to increased DNA content in postnatal myofibre hypertrophy via GRB2–Ras–Raf–MEK–ERK sub-pathway; INSR, PDK1, IRS1 and eIF4E may contribute to high growth rate via stimulating the rate of protein synthesis and inhibiting the rate of protein degradation. In addition, the results suggested 60 days maybe a very important stage in postnatal myofibre growth. Moreover, higher mRNA level of IRS1 and GLUT4 maybe associated with inferior meat quality in Yorkshire compared to Tongcheng pig. Therefore, IGFI signaling pathway regulates myofibre hypertrophy postnatally via complicated signal effectors, which may have negative impact on meat quality simultaneously.

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Acknowledgments

This work was financially supported by the National Natural Science Foundation of China (30400313), the National Key Foundation Research and Development Program of China (2006CB102102) and the National High Technology Research and Development Program of China (2006AA10Z1D6).

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Affiliations

  1. Key Laboratory of Swine Genetics and Breeding, Ministry of Agriculture, Wuhan, People’s Republic of China

    Qingzhen Jiao, Minggang Lei, Linjie Wang, Xiaoyu Mo, Jing Lan & Yuanzhu Xiong

  2. Key Lab of Agriculture Animal Genetics, Breeding and Reproduction, Ministry of Education, Wuhan, People’s Republic of China

    Qingzhen Jiao, Minggang Lei, Linjie Wang, Xiaoyu Mo, Jing Lan & Yuanzhu Xiong

  3. College of Animal Science, Huazhong Agricultural University, Wuhan, Hubei, 430070, People’s Republic of China

    Qingzhen Jiao, Minggang Lei, Linjie Wang, Xiaoyu Mo, Jing Lan & Yuanzhu Xiong

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  1. Qingzhen Jiao
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  2. Minggang Lei
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  3. Linjie Wang
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  4. Xiaoyu Mo
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  5. Jing Lan
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  6. Yuanzhu Xiong
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Correspondence to Minggang Lei.

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Jiao, Q., Lei, M., Wang, L. et al. Developmental expression changes of the genes involved in IGFI signaling pathway in longissimus dorsi muscle of Tongcheng and Yorkshire pigs during postnatal growth. Mol Biol Rep 38, 5133–5138 (2011). https://doi.org/10.1007/s11033-010-0662-5

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  • DOI: https://doi.org/10.1007/s11033-010-0662-5

Keywords

  • Postnatal myofibre growth
  • IGFI signaling pathway
  • Developmental expression
  • Meat production and quality
  • Pig