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Association of gene polymorphisms in prolactin and its receptor with breast cancer risk in Taiwanese women

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Abstract

Given the essential role of prolactin (PRL) and its receptor (PRLR) in breast tumorigenesis, we investigated whether single nucleotide polymorphisms (SNPs) in the PRL and PRLR genes were associated with breast cancer in Taiwanese women. A total of 160 breast cancer patients and 336 unrelated control Taiwanese women were enrolled in this study. Three SNPs (rs1341238, rs2244502 and rs3756824) in the PRL gene and one SNP (rs10941235) in the PRLR gene were genotyped using allele-specific polymerase chain reaction and DNA sequencing. We showed that the PRLR SNP rs10941235 was associated with breast cancer (P < 0.05) and its genotype frequencies in the breast cancer group were significantly associated (P < 0.05) with the levels of cancer antigen 15-3, a serum biomarker of breast cancer. The PRL SNP rs3756824 was significantly associated with breast cancer metastasis (P < 0.05). These findings suggest that the polymorphism rs10941235 in the PRLR gene is associated with breast cancer and cancer antigen 15-3 levels in Taiwanese women.

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Acknowledgements

This work was supported by Asia-Pacific Biotech Developing Inc., Taiwan.

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Authors and Affiliations

  1. Division of General Surgery, Department of Surgery, ZuoYing Armed Forces General Hospital, Kaohsiung, Taiwan

    Fan-Yun Mong

  2. School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan

    Yu-Liang Kuo

  3. Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

    Yu-Liang Kuo

  4. Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung County, Taiwan

    Ching-Wen Liu

  5. Asia-Pacific Biotech Developing, Inc., Kaohsiung, Taiwan

    Wen-Sheng Liu

  6. Department of Occupational Therapy, I-Shou University, Kaohsiung, Taiwan

    Li-Ching Chang

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  1. Fan-Yun Mong
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  2. Yu-Liang Kuo
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  3. Ching-Wen Liu
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  4. Wen-Sheng Liu
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Correspondence to Li-Ching Chang.

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Mong, FY., Kuo, YL., Liu, CW. et al. Association of gene polymorphisms in prolactin and its receptor with breast cancer risk in Taiwanese women. Mol Biol Rep 38, 4629–4636 (2011). https://doi.org/10.1007/s11033-010-0596-y

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  • DOI: https://doi.org/10.1007/s11033-010-0596-y

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