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Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility

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Abstract

Several polymorphisms of vascular endothelial growth factor (VEGF) such as 936 C/T, −2578 C/A, −406 C/T, and −1154 G/A polymorphism have been identified. Published data on the association between VEGF polymorphisms and breast cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. Crude OR with 95% CI was used to assess the strength of association between them. For VEGF 936C/T polymorphism, a total of 10 studies including 7,685 cases and 7,915 controls were involved in this meta-analysis. Overall, no significant associations were found between VEGF 936C/T polymorphism and breast cancer risk when all studies pooled into the meta-analysis (TC vs. CC: OR = 0.904, 95% CI = 0.797–1.024; TT vs. CC: OR = 0.974, 95% CI = 0.786–1.205; dominant model: OR = 0.911, 95% CI = 0.811–1.024; and recessive model: OR = 0.991, 95% CI = 0.801–1.226). In the subgroup analysis by ethnicity, still no significant associations were found for all comparison models. For −2578 C/A, −406 C/T, and −1154 G/A polymorphism, there were too limited data to perform a meta-analysis. In conclusion, this meta-analysis suggests that the VEGF 936C/T polymorphism may be not associated with breast cancer development. However, large sample and representative population-based studies with homogeneous breast cancer patients and well matched controls are warranted to confirm this finding.

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Conflict of interest statement

All authors declared no potential conflicts of interest.

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Authors and Affiliations

  1. Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

    Li-Xin Qiu, Jian Zhang, Qun-Ling Zhang, Si Sun & Kai Xue

  2. Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

    Li-Xin Qiu, Jian Zhang, Qun-Ling Zhang, Si Sun & Kai Xue

  3. Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China

    Ke Wang

  4. Department of Medical Oncology, Union Hospital, Fu Jian Medical University, Fuzhou, China

    Sheng Yang

  5. Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China

    Chen Mao

  6. Department of Epidemiology, School of Public Health, Wuhan University, Wuhan, China

    Lei Zhao

  7. State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China

    Lei Yao

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  1. Li-Xin Qiu
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  2. Ke Wang
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  3. Sheng Yang
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  4. Chen Mao
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  7. Jian Zhang
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  8. Qun-Ling Zhang
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  9. Si Sun
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  10. Kai Xue
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Correspondence to Li-Xin Qiu.

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Li-Xin Qiu and Ke Wang contributed equally to this work and should be considered as co-first authors.

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Qiu, LX., Wang, K., Yang, S. et al. Current evidences on vascular endothelial growth factor polymorphisms and breast cancer susceptibility. Mol Biol Rep 38, 4491–4494 (2011). https://doi.org/10.1007/s11033-010-0579-z

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  • DOI: https://doi.org/10.1007/s11033-010-0579-z

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