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Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population

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Abstract

The glutathione S-transferase (GST) family of enzymes is known to play a pivotal role in phase II of biotransformation of xenobiotics, environmental carcinogens and pharmacological drugs. The objective of the present study was to investigate the role of GSTM1 and GSTT1 null genotypes as risk factors for chronic obstructive pulmonary disease (COPD) and prostate cancer. The subjects appraised were 200 COPD cases, 150 prostate cancer cases, 150 benign prostatic hyperplasia (BPH) cases, 200 age matched controls for COPD and 172 age matched controls for prostate cancer. GSTM1 and GSTT1 null genotype was found to confer 2.5 (OR 2.45; 95% CI 1.56–3.82; P value = 0.00008) and 2.4-fold (OR 2.39; 95% CI 1.36–4.20; P value = 0.002) significant higher risk for prostate cancer. Smoking imparted a 2.2-fold significant risk of prostate cancer cases (OR 2.23; 95% CI 1.36–3.65 P value = 0.001) and twofold risk in BPH (OR 2.09; 95% CI 1.26–3.46; P value = 0.005). In case of COPD only null genotype of GSTT1 has shown 2.1-fold (OR 2.11; 95% CI 1.22–3.62; P value = 0.007) significant increased risk.

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Acknowledgments

The research was supported by Indian council of medical research, New Delhi for financial assistance. The authors are grateful to Prof. R. C. Sobti, Vice-Chancellor Panjab University and Staff of respective departments of respective premier institutes for the cooperation and assistance for collection of samples.

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Authors and Affiliations

  1. Department of Biotechnology, Panjab University, Chandigarh, India

    Hitender Thakur, Lipsy Gupta & Ranbir C. Sobti

  2. Department of Pulmonary Medicine, Govt Medical College and Hospital, Chandigarh, India

    Ashok K. Janmeja

  3. Department of Urology, All India Institute of Medical Sciences, New Delhi, India

    Amlesh Seth

  4. Department of Urology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160014, India

    Sharwan K. Singh

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  1. Hitender Thakur
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Correspondence to Lipsy Gupta.

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Thakur, H., Gupta, L., Sobti, R.C. et al. Association of GSTM1T1 genes with COPD and prostate cancer in north Indian population. Mol Biol Rep 38, 1733–1739 (2011). https://doi.org/10.1007/s11033-010-0287-8

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  • DOI: https://doi.org/10.1007/s11033-010-0287-8

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