Molecular Biology Reports

, Volume 38, Issue 2, pp 873–878 | Cite as

The emerging role of adipokines in osteoarthritis: a narrative review

  • Peng-fei Hu
  • Jia-peng Bao
  • Li-dong Wu


Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.


Adipokines Osteoarthritis Leptin Adiponectin Resistin Visfatin 



This work was supported by grants from Health Bureau of Zhejiang Province (2006A055).


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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Zhejiang University College of MedicineHangzhouPeople’s Republic of China
  2. 2.Department of Orthopedics Surgery, The Second Hospital of Medical CollegeZhejiang UniversityHangzhouPeople’s Republic of China

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