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Glutamate receptors and signal transduction in learning and memory

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Abstract

The plasticity of the central nervous system helps form the basis for the neurobiology of learning and memory. Long-term potentiation (LTP) is the main form of synaptic plasticity, reflecting the activity level of the synaptic information storage process, and provides a good model to study the underlying mechanisms of learning and memory. The glutamate receptor-mediated signal pathway plays a key role in the induction and maintenance of LTP, and hence the regulation of learning and memory. The progress in the understanding of the glutamate receptors and related signal transduction systems in learning and memory research are reviewed in this article.

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Acknowledgements

This work was financially supported by the Grants from the Medical Scientific Research Foundation of Jiangsu Province, PR China (Grant No. H200645); and the Science Foundation of the Health Bureau. Wuxi City, PR China (Grant No. XM0805).

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Authors and Affiliations

  1. Department of Anesthesiology, Affiliated No. 4 Hospital of Soochow University, Wuxi, 214062, People’s Republic of China

    Sheng Peng, Yan Zhang, Jiannan Zhang, Hua Wang & Bingxu Ren

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  1. Sheng Peng
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  2. Yan Zhang
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  3. Jiannan Zhang
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  4. Hua Wang
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Correspondence to Yan Zhang.

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Peng, S., Zhang, Y., Zhang, J. et al. Glutamate receptors and signal transduction in learning and memory. Mol Biol Rep 38, 453–460 (2011). https://doi.org/10.1007/s11033-010-0128-9

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