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Vitamin D receptor genotypes and kidney allograft rejection

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Abstract

Objective Transplantation of renal grafts is an established treatment for renal failure in a variety of medical conditions. Polymorphisms in genes, coding for proteins involved in immune response, may influence immunological and non-immunological mechanisms that lead to allograft loss. Vitamin D receptor (VDR) agonist has been shown to reduce short and long term allograft rejection in animal model. There are functional polymorphisms in VDR gene. Materials and methods A total of 75 renal allograft recipients with at least 2 years follow-up were selected and genotyped for two polymorphisms in the VDR genes (FokI and BsmI) and the association of each genotype with renal allograft survival and acute rejection was evaluated. Results We are unable to find statistically significant association between any of the study polymorphisms and clinical outcomes. Conclusion We have found no evidence to suggest that either VDR FokI or BsmI polymorphism determines the incidence of acute rejection or graft survival after renal transplantation. A larger sample size is necessary to confirm these findings.

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Authors and Affiliations

  1. Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351, Shiraz, Iran

    Negar Azarpira, Bita Geramizadeh & Masumeh Darai

  2. Organ Transplantation Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351, Shiraz, Iran

    Mohamad M. Sagheb

Authors
  1. Negar Azarpira
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  2. Mohamad M. Sagheb
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  3. Bita Geramizadeh
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  4. Masumeh Darai
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Correspondence to Negar Azarpira.

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Azarpira, N., Sagheb, M.M., Geramizadeh, B. et al. Vitamin D receptor genotypes and kidney allograft rejection. Mol Biol Rep 36, 2387–2392 (2009). https://doi.org/10.1007/s11033-009-9467-9

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  • DOI: https://doi.org/10.1007/s11033-009-9467-9

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