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Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle

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Abstract

GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle. The mutations at nt456(G > A) and nt667(C > T) were complete linkage and located in exon 1 of the coding region of the GHSR gene. Least squares analysis revealed a significant statistical effect (P < 0.05) of the GHSR gene different genotypes on body weight and average daily gain at 6 months of age in Nanyang cattle. Individuals with GHSR-MM genotype showed higher body weight and average daily gain than individuals with GHSR-MN genotype.

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Acknowledgments

This study was supported by the National 863 Program of China (No. 2006AA10Z197), National Natural Science Foundation of China (No. 30771544), National Key Technology R&D Program (No. 2006BAD01A10-5), Innovative Foundation of Outstanding Talent from Henan Province (No. 0521001900), Sustaining Program for Topnotch Persons of Northwest A&F University (No. 01140101), and Natural Science Foundation of Xuzhou Normal University and Talent Foundation of Northwest A&F University, Basic and Foreland Technology Study Program of Henna Province (No. 072300430160), “13115” Sci-Tech Innovation Program of Shaanxi Province (2008ZDKG-11).

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Authors and Affiliations

  1. College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Northwest A&F University, 712100, Yangling, Shaanxi, China

    Bao Zhang, Hong Chen, Yikun Guo, Liangzhi Zhang, Miao Zhao, Xianyong Lan, Chuanying Pan, Shenrong Hu & Chuzhao Lei

  2. Institute of Cellular and Molecular Biology, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, China

    Hong Chen & Chunlei Zhang

  3. Research Center of Cattle Engineering Technology in Henan, 450003, Zhengzhou, Henan, Peoples Republic of China

    Juqiang Wang

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  1. Bao Zhang
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  2. Hong Chen
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Correspondence to Hong Chen.

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Zhang, B., Chen, H., Guo, Y. et al. Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle. Mol Biol Rep 36, 2259–2263 (2009). https://doi.org/10.1007/s11033-008-9442-x

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  • DOI: https://doi.org/10.1007/s11033-008-9442-x

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