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Toll-like receptor 8 polymorphism and coronary artery disease

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Abstract

Toll-like receptors (TLRs) play roles in innate and adaptive immune responses. Some TLRs are involved in the pathogenesis of cardiovascular diseases. Coronary artery disease (CAD) has an inflammatory and immunological basis. We investigated whether TLR8 Met1Val and TLR8-129G>C single nucleotide polymorphisms (SNPs rs3764879 and rs3764880) are associated with CAD in the Chinese population. We enrolled 412 consecutive patients (185 with coronary stenosis ≥50% or previous myocardial infarction and 227 controls). Ligase detection reaction was performed to detect SNPs rs3764879 and rs3764880 of TLR8. The SNP at rs3764879 is in complete linkage disequilibrium with rs3764880. No significant difference was found in genotypic or allelic frequencies of these two common SNPs between CAD cases and controls (P > 0.05, respectively). No associations existed between these two SNPs and the severity of coronary artery stenosis (All P > 0.05). These results do not support an involvement of SNPs rs3764879 and rs3764880 of TLR8 in predisposition to CAD.

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Abbreviations

CAD:

Coronary artery disease

SAP:

Stable angina pectoris

UAP:

Unstable angina pectoris

MI:

Myocardial infarction

CI:

Confidence interval

OR:

Odds ratio

SNP:

Single nucleotide polymorphism

TLR:

Toll-like receptors

LDL-C:

Low-density lipoprotein cholesterol

PAMPs:

Pathogen-associated molecular patterns

PRRs:

Pattern recognition receptors

EV:

Enterovirus

DCM:

Dilated cardiomyopathy

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Acknowledgments

This study was supported by Nanjing Scientific Development Grant for 2006 (2006ZD016).

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Authors and Affiliations

  1. Department of Cardiology, The Affiliated ZhongDa Hospital of Southeast University, NO. 87 Dingjiaqiao, Hunan Road, Nanjing, 210009, People’s Republic of China

    Zhong Chen, Genshan Ma, Qi Qian, Yuyu Yao, Yi Feng & Chengchun Tang

Authors
  1. Zhong Chen
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  2. Genshan Ma
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  3. Qi Qian
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  4. Yuyu Yao
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  5. Yi Feng
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  6. Chengchun Tang
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Corresponding author

Correspondence to Zhong Chen.

Additional information

Z. Chen and G. Ma contributed equally to this paper.

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Chen, Z., Ma, G., Qian, Q. et al. Toll-like receptor 8 polymorphism and coronary artery disease. Mol Biol Rep 36, 1897–1901 (2009). https://doi.org/10.1007/s11033-008-9396-z

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  • DOI: https://doi.org/10.1007/s11033-008-9396-z

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