Abstract
The small molecules already existing on the earth can be assembled to biological macromolecules in the presence of the suitable tool. A workman must sharpen his tools if he is to do his work well. The tool must be specific, delicate and automatic. Obviously, it is enzyme. Therefore, to explore the origin of life we must understand the origin of the manufacturing tool of biological macromolecules—the origin of enzymes. We can understand more about the origin and evolution procedures of enzymes from the NO2. NO2 can easily form the dimmer, N2O4. Four N2O4 molecules can coordinate with a suitable metal ion and form a plane super molecule with four N2O4 molecules. This supramolecule provides the basis for the appearance of enzymes: (1) It is the template for producing enzymes. (2) It provides the active centers for enzymes. (3) It provides for the enzymes with specific function of chiral selection. This supramolecule reacts with formaldehyde and porphyrin compound is gradually formed. Once suitable function groups are substituted on the porphyrin ring, enzymes are formed. The primitive environment of earth can easily produce NO2 and CH2O. Therefore, this might be one clue to the origin of life.
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Notes
Simulation experiment of the beginning of the living stuffs by Stanley Miller: in 1953, Stanley Miller, put gas water, CH4, NH3 and H2 in a closed container. These four gases were subjected to the action of an electric discharge. A mixture of 20 organic compounds including 11 amino acids was collected.
In March 1995, Science reported that the international meeting held in Los Angeles about the origin of biological molecular homochirality. Most physicists, chemists and astronomers thought that 'there is no life without chirality', 'chirality is originated from life'. Currently, most scientists do not believe the secret life selection or ‘spontaneous symmetry breaking’. They insist on finding some physical reasons.
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Yin, X., Yuan, Z. A clue to the origin of life: begin from making tools. Mol Biol Rep 36, 371–375 (2009). https://doi.org/10.1007/s11033-007-9189-9
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DOI: https://doi.org/10.1007/s11033-007-9189-9