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Genetic polymorphism c.1438A>G of the 5-HT2A receptor is associated with abdominal obesity in Chinese Northern Han population

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Abstract

Objective We examined the potential impact of the 5-hydroxytryptamine 2A receptor (5-HT2AR) c.1438A>G promoter polymorphism on obesity and estimates of insulin, glucose as well as lipid metabolism. Methods The genotypes and allelic frequencies of the 5-HT2AR c.1438A>G were examined with polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) in 210 patients with overweight/obesity and 216 unrelated healthy subjects. Results The genotype (AA, AG, and GG) distribution of c.1438A>G polymorphism of the 5-HT2AR gene promoter was 35%, 46%, and 19% in patients, and 32%, 56%, 12% in controls, respectively, no significant difference was found between two groups. Association of genetic diversity of 5-HT2AR c.1438A>G with the total body fat, fat distribution and clinical characteristics revealed that overweight/obese men carrying G allele were associated with increased body mass index (P = 0.043), waist circumference (P = 0.038), waist-to-hip ratio (P = 0.045), in comparison with patients who carrying A allele, but there were no significant difference between the c.1438A>G genotype groups in overweight/obese women. Conclusion No significant associations were detected. However, the present study suggests the possibility that an abnormal production rate of the 5-HT2AR c.1438A>G gene product might lead to the development of abdominal obesity in men but not in women.

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Authors and Affiliations

  1. Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China

    Su Ying, Xiao-Min Liu & Shang-Ha Pan

  2. Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China

    Yan-Ming Sun

Authors
  1. Su Ying
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  2. Xiao-Min Liu
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  3. Yan-Ming Sun
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  4. Shang-Ha Pan
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Correspondence to Su Ying.

Additional information

Su Ying and Yan-Ming Sun equally contributed to this study.

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Ying, S., Liu, XM., Sun, YM. et al. Genetic polymorphism c.1438A>G of the 5-HT2A receptor is associated with abdominal obesity in Chinese Northern Han population. Mol Biol Rep 36, 91–95 (2009). https://doi.org/10.1007/s11033-007-9155-6

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  • DOI: https://doi.org/10.1007/s11033-007-9155-6

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