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Frequency distribution of the G/A alleles of the β-fibrinogen gene in the Lebanese population

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Abstract

Fibrinogen is a plasma protein that has been reported to be associated with an increased risk of atherothrombotic diseases and venous thrombosis. The most common polymorphism that has been studied so far in different populations is the G-455→A polymorphism in the promoter region of the β-fibrinogen gene. We studied 160 healthy unrelated Lebanese individuals for the prevalence of -455G/G, -455G/A and -455A/A genotypes of the β-fibrinogen gene and the frequency of G and A alleles using a reverse hybridization PCR assay. The prevalence of the G/G, G/A, and A/A genotypes were found to be 60.6, 31.9 and 7.5%, respectively. The frequency of the G and A alleles were found to be 0.77 and 0.23, respectively. As compared to other ethnic groups, the Lebanese individuals were found to have a relatively high prevalence of the A allele which may predispose them to develop cardiovascular diseases as well as thrombotic events. This study provides additional unique genetic information pertaining to the Lebanese population.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, American University of Beirut Medical Center, Riad El Solh, P.O. Box 11-0236, Beirut, 1107 2020, Lebanon

    Dina M. R. Shammaa, Amira S. Sabbagh, Ghazi S. Zaatari & Rami A. R. Mahfouz

  2. Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

    Ali T. Taher

Authors
  1. Dina M. R. Shammaa
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  2. Amira S. Sabbagh
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  4. Ghazi S. Zaatari
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  5. Rami A. R. Mahfouz
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Correspondence to Rami A. R. Mahfouz.

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Shammaa, D.M.R., Sabbagh, A.S., Taher, A.T. et al. Frequency distribution of the G/A alleles of the β-fibrinogen gene in the Lebanese population. Mol Biol Rep 35, 307–311 (2008). https://doi.org/10.1007/s11033-007-9087-1

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  • DOI: https://doi.org/10.1007/s11033-007-9087-1

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