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No association between polymorphism in the vascular endothelial growth factor gene at position−460 and sporadic prostate cancer in the Turkish population

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Abstract

The development and progression of prostate cancer (PCa) has biologically and genetically remained a mystery. A man’s risk of developing PCa is influenced by both genetic and environmental factors. Angiogenic cytokines like vascular endothelial growth factor (VEGF) play a pivotal role in tumor angiogenesis. Single nucleotide polymorphisms in angiogenesis-dependent genes affect the sensibility of cancer development and progression. Therefore, we hypothesized a potential association between DNA sequence variations in VEGF −460 gene region and sporadic PCa patients in the Turkish population. 133 sporadic PCa patients and 157 healthy controls were studied. Genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. The distribution of genotype and allele frequencies of the polymorphism did not yield a statistically significant difference between patients and controls (P > 0.05). Furthermore, classification of patients by tumor-lymph nodes-metastasis (TNM), Gleason Scores (GS) and serum prostate-specific antigen (PSA) levels did not show significant differences among the VEGF −460 C>T genotypes (P > 0.05). This is the first demonstration showing that the VEGF −460 C>T polymorphism in men is not associated with sporadic PCa in the Turkish population.

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Acknowledgments

This study has been partially supported by the Gazi University Research Fund, with the project code number 11/2003-05.

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Authors and Affiliations

  1. Department of Medical Biology and Genetics, Faculty of Medicine, Gazi University, Besevler, Ankara, 06510, Turkey

    Ilke H. Onen, Ece Konac & Abdullah Ekmekci

  2. Department of Urology, Faculty of Medicine, Abant Izzet Baysal University, Golkoy, Bolu, Turkey

    Muzaffer Eroglu

  3. Department of Urology, Faculty of Medicine, Gazi University, Besevler, Ankara, Turkey

    Cagri Guneri & Hasan Biri

Authors
  1. Ilke H. Onen
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  2. Ece Konac
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Correspondence to Ece Konac.

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Onen, I.H., Konac, E., Eroglu, M. et al. No association between polymorphism in the vascular endothelial growth factor gene at position−460 and sporadic prostate cancer in the Turkish population. Mol Biol Rep 35, 17–22 (2008). https://doi.org/10.1007/s11033-006-9046-2

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  • DOI: https://doi.org/10.1007/s11033-006-9046-2

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