Dynamic measures of anxiety-related threat bias: Links to stress reactivity
Exaggerated attention to threatening information, or the threat bias, has been implicated in the development and maintenance of anxiety disorders. Recent research has highlighted methodological limitations in threat bias measures, such as temporal insensitivity, leading to the development of novel metrics that capture change and variability in threat bias over time. These metrics, however, have rarely been examined in non-clinical samples. The present study aimed to explore the utility of these trial-level metrics in predicting anxiety-related stress reactivity (stress-induced negative mood state) in trait anxious adults (N = 52). Following a stressor, participants completed the dot probe task to generate threat bias scores. Stress reactivity was measured via stress-induced changes in subjective mood state. More variability in trial-level bias scores (TL-BSs) and greater bias away from threat (both mean and peak negative TL-BSs) predicted increased stress reactivity. The temporal characteristics of threat bias and implications for clinically-relevant measurement are discussed.
KeywordsAnxiety Threat bias Trial-level bias score Stress reactivity
The contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIMHD or the NIH.
This research was made possible by grant SC1MH104907 awarded to TDT from the National Institute of General Medical Sciences and grant R56MH111700 awarded to TDT from the National Institute of Mental Health, both of the National Institutes of Health. This research was also made possible by grant TR000457 of the National Center for Advancing Translational Sciences of the National Institutes of Health.
- Bar-Haim, Y., Lamy, D., Pergamin, L., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007). Threat-related attentional bias in anxious and nonanxious individuals: A meta-analytic study. Psychological Bulletin, 133(1), 1–24. https://doi.org/10.1037/0033-2909.133.1.1.CrossRefPubMedGoogle Scholar
- Beck, A. T. (1987). Cognitive models of depression. Journal of Cognitive Psychotherapy, 1, 5–38.Google Scholar
- Brown, H. M., Eley, T. C., Broeren, S., MacLeod, C., Rinck, M., Hadwin, J. A., & Lester, K. J. (2014). Psychometric properties of reaction time based experimental paradigms measuring anxiety-related information-processing biases in children. Journal of Anxiety Disorders, 28, 97–107. https://doi.org/10.1016/j.janxdis.2013.11.004.CrossRefPubMedGoogle Scholar
- Eysenck, M. W. (1992). Anxiety: The cognitive perspective. Hillsdale, NJ: Erlbaum.Google Scholar
- Koster, E. H. W., Crombez, G., Verschuere, B., & De Houwer, J. (2004). Selective attention to threat in the dot probe paradigm: Differentiating vigilance and difficulty to disengage. Behaviour Research and Therapy, 42, 1183–1192. https://doi.org/10.1016/j.brat.2003.08.001.CrossRefPubMedGoogle Scholar
- Koster, E. H. W., Crombez, G., Verschuere, B., Van Damme, S., & Wiersema, J. R. (2006). Components of attentional bias to threat in high trait anxiety: Facilitated engagement, impaired disengagement, and attentional avoidance. Behaviour Research and Therapy, 44, 1757–1771. https://doi.org/10.1016/j.brat.2005.12.011.CrossRefPubMedGoogle Scholar
- Lang, P., Bradley, M., & Cuthbert, B. (2008). International affective picture system (IAPS): Affective ratings of pictures and instruction manual (Rep. No. A-8). Technical Report A-8.Google Scholar
- LeDoux, J. (1996). The emotional brain. New York: Simon & Schuster.Google Scholar
- Lee, J. K., Orsillo, S. M., Roemer, L., & Allen, L. B. (2010). Distress and avoidance in generalized anxiety disorder: Exploring the relationships with intolerance of uncertainty and worry. Cognitive Behaviour Therapy, 39(2), 126–136. https://doi.org/10.1080/16506070902966918.CrossRefPubMedPubMedCentralGoogle Scholar
- MacLeod, C., Campbell, E., Rutherford, L., & Wilson, E. (2004). The causal status of anxiety-linked attentional and interpretive bias. In J. Yiend (Ed.), Cognition, emotion and psychopathology: Theoretical, empirical and clinical directions (pp. 172–189). New York: Cambridge University Press.CrossRefGoogle Scholar
- MacLeod, C., Rutherford, E., Campbell, L., Ebsworthy, G., & Holker, L. (2002). Selective attention and emotional vulnerability: Assessing the causal basis of their association through the experimental manipulation of attentional bias. Journal of Abnormal Psychology, 111(1), 107–123. https://doi.org/10.1037//0021-843X.111.1.107.CrossRefPubMedGoogle Scholar
- McNair, D. M., Lorr, M., Heuchert, J. W. P., & Droppleman, L. F. (2003). Profile of mood states: Standard form. North Tonawanda, NY: Multi-Health Systems (MHS).Google Scholar
- Monk, C. S., Nelson, E. E., McClure, E. B., Mogg, K., Bradley, B. P., Leibenluft, E., et al. (2006). Ventrolateral prefrontal cortex activation and attentional bias in response to angry faces in adolescents with generalized anxiety disorder. American Journal of Psychiatry, 163(6), 1091–1097. https://doi.org/10.1176/appi.ajp.163.6.1091.CrossRefPubMedGoogle Scholar
- Price, R. B., Kuckertz, J. M., Siegle, G. J., Ladouceur, C. D., Silk, J. S., Ryan, N. D., et al. (2015). Empirical recommendations for improving the stability of the dot-probe task in clinical research. Psychological Assessment, 27(2), 365–376. https://doi.org/10.1037/pas0000036.CrossRefPubMedGoogle Scholar
- Rodebaugh, T. L., Scullin, R. C., Langer, J. K., Dixon, D. J., Juppert, J. D., Bernstein, A., Zvielli, A., et al. (2016). Unreliability as a threat to understanding psychopathology: The cautionary tale of attentional bias. Journal of Abnormal Psychology, 125(6), 840–851. https://doi.org/10.1037/abn0000184.CrossRefPubMedPubMedCentralGoogle Scholar
- Roy, A. K., Dennis, T. A., & Warner, C. M. (2015). A critical review of attentional threat bias and its role in the treatment of pediatric anxiety disorders. Journal of Cognitive Psychotherapy: An International Quarterly, 29(3), 171–184. https://doi.org/10.1891/0889-8322.214.171.124.CrossRefGoogle Scholar
- Spielberger, C. D. (1983). State-trait anxiety inventory manual. Redwood City, CA: Mind Garden, Inc.Google Scholar
- Williams, J. M. G., Watts, F. N., MacLeod, C., & Mathews, A. (1997). Cognitive psychology and emotional disorders (2nd ed.). Chichester: Wiley.Google Scholar