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Precision in stereochemistry: the integral role of catalytic asymmetric Biginelli reaction in crafting enantiomerically pure dihydropyrimidinones

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Abstract

One well-known multicomponent reaction that is helpful in the synthesis of dihydropyrimidinones (DHPMs), important molecules in organic synthesis and medicinal chemistry, is the Biginelli reaction. Because of their wide range of biological activities, DHPMs are regarded as essential chemicals. A great deal of research has been done in the last few decades to find ways to produce enantiomerically pure DHPMs because of their notable and focused target-oriented biological activities. In this reaction, numerous structural variants and catalysts have been employed in a range of solvents to yield an enormous number of Biginelli-type compounds. In the present review, the available catalysts in the literature including ionic liquids, Lewis acids, and organocatalysts for the Biginelli reaction and synthesis of a large number of asymmetric compounds since 2003 are summarized.

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Acknowledgements

We are grateful for support from the Presidency University, Karnataka, India, and the Research Council of Shoushtar Branch, Islamic Azad University, Shoushtar, Iran.

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Authors and Affiliations

  1. Department of Chemistry, Presidency University, Rajanukunte, Itgalpura, Bangalore, Karnataka, 560064, India

    Anjaneyulu Bendi

  2. Department of Chemistry, Faculty of Science, SGT University, Gurugram, Haryana, 122505, India

    Anirudh Singh Bhathiwal

  3. Intertek India, Udyog Vihar, Phase I, Dundahera Village, Gurugram, Haryana, 122001, India

    Aditi Tiwari

  4. Department of Chemistry, Kommuri Pratap Reddy Institute of Technology, Hyderabad, Telangana, 500088, India

    G. B. Dharma Rao

  5. Department of Chemistry, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran

    Mozhgan Afshari

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  1. Anjaneyulu Bendi
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  3. Aditi Tiwari
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Contributions

All authors contributed to the concept and design of the study. Data collection and analysis were performed by A.S.B and A.T. The first draft of the manuscript was written by A.B and G.B.D.R, and all authors commented on previous versions of the manuscript. M.A performed and revised the final document. All authors have read the final version of the manuscript and consented to its publication.

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Correspondence to Anjaneyulu Bendi or Mozhgan Afshari.

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Bendi, A., Bhathiwal, A.S., Tiwari, A. et al. Precision in stereochemistry: the integral role of catalytic asymmetric Biginelli reaction in crafting enantiomerically pure dihydropyrimidinones. Mol Divers (2024). https://doi.org/10.1007/s11030-024-10827-7

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