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Iron-catalyzed intermolecular cross-dehydrogenative C(sp3)–H/C(sp)–H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes

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Abstract

A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones systems and terminal alkynes was established. This methodology offers a high yielding, straightforward, and one-pot approach towards the synthesis of alkynylated 4-thiazolidinones without prior activation of C(sp3)–H and C(sp)–H. The results of control experiments indicated that this conversion might proceed via a radical process.

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Acknowledgements

Authors are thankful to IISER-Pune and IIT-Bombay for the spectral analysis. Authors express their gratitude to Head of Chemistry Department, Veer Narmad South Gujarat University, Surat, to provide necessary laboratory facilities.

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  1. Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India

    Mayur I. Morja & Kishor H. Chikhalia

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  1. Mayur I. Morja
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  2. Kishor H. Chikhalia
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Correspondence to Kishor H. Chikhalia.

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Morja, M.I., Chikhalia, K.H. Iron-catalyzed intermolecular cross-dehydrogenative C(sp3)–H/C(sp)–H coupling of pyrimidine bearing 4-thiazolidinones with terminal alkynes. Mol Divers 26, 3037–3045 (2022). https://doi.org/10.1007/s11030-021-10363-8

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