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A green method for the synthesis of pyrrole derivatives using arylglyoxals, 1,3-diketones and enaminoketones in water or water–ethanol mixture as solvent

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Abstract

Three-component reaction between arylglyoxals, 1,3-dicetones and enaminoketones leads to new polyfunctionalized tetraone derivatives which may be easily converted to polyfunctionalized pyrroles. Reactions were conducted in water or water–ethanol mixture as green solvents, and all products were isolated by simple washing of the resulting solids with diethyl ether.

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Acknowledgements

We gratefully acknowledge the Vail-e-Asr University of Rafsanjan Faculty Research Grant for financial support.

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  1. Department of Chemistry, Vali-e-Asr University, Rafsanjan, 77176, Iran

    Mohammad Anary-Abbasinejada, Frershteh Nezhad-Shshrokhabadi & Marziyeh Mohammadi

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  1. Mohammad Anary-Abbasinejada
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Anary-Abbasinejada, M., Nezhad-Shshrokhabadi, F. & Mohammadi, M. A green method for the synthesis of pyrrole derivatives using arylglyoxals, 1,3-diketones and enaminoketones in water or water–ethanol mixture as solvent. Mol Divers 24, 1205–1222 (2020). https://doi.org/10.1007/s11030-019-09984-x

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