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Green pseudo-multicomponent synthesis of some new spirocyclopropane derivatives via electro-catalyzed reaction

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Abstract

Due to the diverse applications of cyclopropane analogs in bioorganic, medicinal, and pharmaceutical chemistry, a clean and efficient procedure was established to synthesize spirocyclopropane via an electrochemical reaction which involves a sequence of Michael addition, halogenation, and intramolecular ring-closing reaction. In this study, an environmentally benign synthesis of spirocyclopropane was carried out through the condensation of indan-1,3-dione by aromatic aldehydes or 2-benzylidenemalononitrile derivatives. Constant current electrosynthesis was applied to a mixture of propanol containing sodium bromide as an electrolyte and a brominating agent at room temperature, respectively.

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Authors and Affiliations

  1. Chemistry and Chemical Engineering Research Center of Iran (CCERCI), P.O. Box 14335-186, Tehran, Islamic Republic of Iran

    Ali Asghar Mohammadi & Reza Ahdenov

  2. Department of Chemistry, Karaj Branch, Islamic Azad University, Karaj, Iran

    Somayeh Makarem & Nazila Amiri Notash

Authors
  1. Ali Asghar Mohammadi
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  2. Somayeh Makarem
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  3. Reza Ahdenov
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  4. Nazila Amiri Notash
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Correspondence to Ali Asghar Mohammadi or Somayeh Makarem.

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Mohammadi, A.A., Makarem, S., Ahdenov, R. et al. Green pseudo-multicomponent synthesis of some new spirocyclopropane derivatives via electro-catalyzed reaction. Mol Divers 24, 763–770 (2020). https://doi.org/10.1007/s11030-019-09979-8

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  • DOI: https://doi.org/10.1007/s11030-019-09979-8

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