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A four-component reaction: regio- and chemoselective formation of 7-amino-2-(tert-butyl)-5-aryl-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitrile

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Abstract

A novel one-pot four-component reaction of an aldehyde, malononitrile, hydrazine and 4,4-dimethyl-3-oxopentanenitrile is described. As regio- and chemoselective products, 7-amino-2-(tert-butyl)-5-aryl-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitriles are formed during the course of the reaction.

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Acknowledgements

We gratefully acknowledge financial support from the Research Council of the University of Isfahan.

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Authors and Affiliations

  1. Department of Chemistry, University of Isfahan, P.O. Box 81746-73441, Isfahan, Iran

    Meysam Alizadeh-Kouzehrash & Abbas Rahmati

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  1. Meysam Alizadeh-Kouzehrash
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  2. Abbas Rahmati
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Correspondence to Abbas Rahmati.

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Alizadeh-Kouzehrash, M., Rahmati, A. A four-component reaction: regio- and chemoselective formation of 7-amino-2-(tert-butyl)-5-aryl-4,5-dihydropyrazolo[1,5-a]pyrimidine-6-carbonitrile. Mol Divers 24, 753–761 (2020). https://doi.org/10.1007/s11030-019-09976-x

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