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The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions

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Abstract

4-Hydroxycoumarins are some of the most versatile heterocyclic scaffolds and are frequently applied in the synthesis of various organic compounds. 4-Hydroxycoumarin-based compounds are important among heterocyclic structures due to their biological and pharmaceutical activities. In this study, we provide an overview on the recent applications of 4-hydroxycoumarin in multicomponent reactions for the synthesis of various heterocyclic compounds during the time period of 2015–2018.

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Abbreviations

CAN:

Ceric ammonium nitrate

CECILs:

Crown ether complex cation ionic liquids

DABCO:

1,4-Diazabicyclo[2.2.2]octane

DBU:

1,8-Diazabicyclo[5.4.0]undec-7-ene

DCE:

Dichloroethane

DMAP:

N,N-Dimethyl-4-aminopyridine

EDTA-4Na:

Sodium ethylene diamine tetraacetate

GO NSs:

Graphene oxide nanostructures

LTNPs:

L-Tyrosine-loaded nanoparticles

MAP:

Monoammonium phosphate

MSA:

Molybdate sulfuric acid

MW:

Microwave

NCS:

N-Chlorosuccinimide

NMS:

Nanostructured molten salt

NPs:

Nanoparticles

OBS:

o-Benzenedisulfonimide

PPI:

Potassium phthalimide

PSA:

Phosphosulfonic acid

PS-PTSA:

Polystyrene-supported p-toluenesulfonic acid

p-TSA:

p-Toluenesulfonic acid

SA:

5-Sulfosalicylic acid

SSA-MNPs:

Silica sulfuric acid magnetic nanoparticles

THAM:

Tris-hydroxymethylaminomethane

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Acknowledgements

We are grateful for financial support from the Research Council of Alzahra University.

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  1. Department of Chemistry, Alzahra University, Tehran, Iran

    Ghodsi Mohammadi Ziarani, Razieh Moradi, Tahereh Ahmadi & Parisa Gholamzadeh

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  1. Ghodsi Mohammadi Ziarani
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Mohammadi Ziarani, G., Moradi, R., Ahmadi, T. et al. The molecular diversity scope of 4-hydroxycoumarin in the synthesis of heterocyclic compounds via multicomponent reactions. Mol Divers 23, 1029–1064 (2019). https://doi.org/10.1007/s11030-019-09918-7

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