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Diastereoselective synthesis of cyclohexadienes via tandem cyclization strategies

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Abstract

A new protocol has been developed for the diastereoselective synthesis of 1,3-cyclohexadienes using vinyl malononitriles, dibenzalacetones and NaH as reagents in THF. This transformation is comprised of interesting steps like Michael addition, cyclization and ring-opening reactions.

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Correspondence to Abdolali Alizadeh.

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Alizadeh, A., Bagherinejad, A., Bayat, F. et al. Diastereoselective synthesis of cyclohexadienes via tandem cyclization strategies. Mol Divers 23, 651–656 (2019). https://doi.org/10.1007/s11030-018-9900-x

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  • DOI: https://doi.org/10.1007/s11030-018-9900-x

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