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One-pot solvent-free synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives using Fe3O4@nano-cellulose/TiCl as a bio-based and recyclable magnetic nano-catalyst

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Abstract

The present study describes an efficient and environmentally benign protocol for the synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives. Synthesis is done by one-pot three-component condensation of 2-naphthol, formaldehyde, and primary amines in the presence of Fe3O4@nano-cellulose/TiCl as a bio-based magnetic nano-catalyst under solvent-free conditions at room temperature grinding. This green procedure offers the advantages of high yield, short reaction time, environmental friendliness, easy workup, simple magnetic recovery of the catalyst and its reusability up to ten times without significant loss of catalytic activity. The structure of products was approved by FT-IR, 1H-NMR, 13C-NMR spectroscopy.

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Acknowledgements

The Research Council of Yazd University gratefully acknowledged for the financial support for this work.

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  1. Department of Chemistry, College of Science, Yazd University, P.O. Box 89195-741, Yazd, Islamic Republic of Iran

    Sara Azad & Bi Bi Fatemeh Mirjalili

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  1. Sara Azad
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  2. Bi Bi Fatemeh Mirjalili
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Correspondence to Sara Azad.

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Azad, S., Mirjalili, B.B.F. One-pot solvent-free synthesis of 2,3-dihydro-2-substituted-1H-naphtho[1,2-e][1,3]oxazine derivatives using Fe3O4@nano-cellulose/TiCl as a bio-based and recyclable magnetic nano-catalyst. Mol Divers 23, 413–420 (2019). https://doi.org/10.1007/s11030-018-9884-6

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