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Synthetic applications and methodology development of Chan–Lam coupling: a review

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Abstract

Chan–Lam coupling is one of the most popular and easy methods to perform arylation of amines (N-arylations). This cross-coupling is generally performed by reacting aryl boronate derivatives with a variety of substrates involving nitrogen containing functional groups such as amines, amides, ureas, hydrazine, carbamates. This article summarizes the synthetic applications of this reaction and the efforts of scientists to develop novel and efficient methodologies for this reaction.

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Authors and Affiliations

  1. Department of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan

    Iqra Munir, Ameer Fawad Zahoor, Nasir Rasool, Syed Ali Raza Naqvi & Raheel Ahmad

  2. Department of Applied Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan

    Khalid Mahmood Zia

Authors
  1. Iqra Munir
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  2. Ameer Fawad Zahoor
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  3. Nasir Rasool
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  4. Syed Ali Raza Naqvi
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  5. Khalid Mahmood Zia
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  6. Raheel Ahmad
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Corresponding author

Correspondence to Ameer Fawad Zahoor.

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Munir, I., Zahoor, A.F., Rasool, N. et al. Synthetic applications and methodology development of Chan–Lam coupling: a review. Mol Divers 23, 215–259 (2019). https://doi.org/10.1007/s11030-018-9870-z

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  • DOI: https://doi.org/10.1007/s11030-018-9870-z

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