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Highly efficient synthesis of alkyl and aryl primary thiocarbamates and dithiocarbamates under metal- and solvent-free conditions

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Abstract

A highly efficient, metal-free and solvent-free process is reported for the preparation of novel series of alkyl and aryl primary thiocarbamates and dithiocarbamates through the reaction of aliphatic alcohols, phenols and thiols with thiocyanate salts in the presence of 4-dodecylbenzenesulfonic acid (DBSA) as an inexpensive, readily available and amphipathic acid reagent. All reactions proceeded smoothly, and the products are obtained in good to excellent yields. Using this method, a wide range of structurally diverse primary thiocarbamates was prepared successfully.

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Acknowledgements

Authors gratefully acknowledge the financial support of this work by the Research Council of Shiraz University.

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Authors and Affiliations

  1. Chemistry Department, College of Sciences, Shiraz University, Shiraz, 71946 84795, Iran

    Ali Reza Sardarian & Iman Dindarloo Inaloo

  2. Chemistry Department, College of Sciences, University of Sistan and Baluchestan, Zahedan, 98135, Iran

    Ali Reza Modarresi-Alam

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  1. Ali Reza Sardarian
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Correspondence to Ali Reza Sardarian.

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Sardarian, A.R., Inaloo, I.D. & Modarresi-Alam, A.R. Highly efficient synthesis of alkyl and aryl primary thiocarbamates and dithiocarbamates under metal- and solvent-free conditions. Mol Divers 22, 863–878 (2018). https://doi.org/10.1007/s11030-018-9831-6

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