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Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

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Abstract

Abstract 

In designing of novel insect growth regulators (IGRs), biologically occurring carvacrol has been structurally modified to thiadiazole and oxadiazole moieties. Two series of carvacrol analogs containing 1,3,4-thiadiazole (VIIIa–e) and 1,3,4-oxadiazole (IXa–e) derivatives are designed and synthesized. Their structures are confirmed by FT-IR, \(^{1}\text {H}\) NMR, \(^{13}\)C NMR and LC-MS. IGR activity is tested against Spodoptera litura. Several analogs displayed IGR activity against this insect pest. Compounds VIIIe and IXe displayed relatively good IGR activity with \(\text {GI}_{50 }\)values 117.43 and 108.83 ppm against Spodoptera litura, respectively.

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Synthesis, characterization and evaluation of carvacrol-based 1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives as potent insect growth regulators (IGRs).

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Acknowledgements

Authors are thankful to CSIR, New Delhi, India, for financial assistance under the major research project [F. No. 02 (0130)/13/EMR-II].

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Authors and Affiliations

  1. Department of Pesticides and Agrochemicals, School of Chemical Sciences, North Maharashtra University, Jalgaon, Maharashtra, 425 001, India

    Suresh D. Bagul, Jamatsing D. Rajput & Ratnamala S. Bendre

  2. Indian Agriculture Research Institute, Pusa, New Delhi, India

    Chitra Srivastava

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  1. Suresh D. Bagul
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  2. Jamatsing D. Rajput
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  4. Ratnamala S. Bendre
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Correspondence to Ratnamala S. Bendre.

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Bagul, S.D., Rajput, J.D., Srivastava, C. et al. Insect growth regulatory activity of carvacrol-based 1,3,4-thiadiazoles and 1,3,4-oxadiazoles. Mol Divers 22, 647–655 (2018). https://doi.org/10.1007/s11030-018-9823-6

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