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Recent advances in the development of polycyclic skeletons via Ugi reaction cascades

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Abstract

Isocyanide-based multicomponent reactions are among the most powerful synthetic tools available. Particularly, the isocyanide-based Ugi reaction can allow rapid preparation of \(\alpha \)-aminoacyl amide derivatives and polyazaheterocycles with extensive pharmaceutical applications. Moreover, bridged polyazaheterocycles, including one or more quaternary carbon centers, can be constructed via the Ugi cascade reaction in a few steps. This review will emphasize synthesis and bioactivities of bridged compounds with quaternary centers constructed through Ugi cascade reactions.

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Authors and Affiliations

  1. Chongqing Engineering Laboratory of Targeted and Innovative Therapeutics, Chongqing Key Laboratory of Kinase Modulators as Innovative Medicine, IATTI, Chongqing University of Arts and Sciences, 319 Honghe Ave., Yongchuan, Chongqing, 402160, China

    Jie Lei, Jiang-Ping Meng, Dian-Yong Tang, Zhong-Zhu Chen & Zhi-Gang Xu

  2. Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR, 72205, USA

    Brendan Frett

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  1. Jie Lei
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  2. Jiang-Ping Meng
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  3. Dian-Yong Tang
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  5. Zhong-Zhu Chen
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Correspondence to Zhong-Zhu Chen or Zhi-Gang Xu.

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Lei, J., Meng, JP., Tang, DY. et al. Recent advances in the development of polycyclic skeletons via Ugi reaction cascades. Mol Divers 22, 503–516 (2018). https://doi.org/10.1007/s11030-017-9811-2

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