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Molecular Diversity

, Volume 22, Issue 2, pp 405–446 | Cite as

Recent developments in the synthesis and applications of dihydropyrimidin-2(1H)-ones and thiones

  • Behzad Mohammadi
  • Farahnaz K. Behbahani
Comprehensive Review

Abstract

Dihydropyrimidin-2(1H)-ones/thiones (DHPMs) are important heterocyclic compounds owing to their excellent biological activities and have been widely utilized in pharmaceutical applications. Recently, numerous DHPM derivatives have been prepared. This review covers the synthesis of DHPMs and improved procedures for the preparation of DHPMs from 1995 to 2016.

Keywords

Multicomponent reaction MCRs Three-component reaction Dihydropyrimidin-2(1H)-ones Dihydropyrimidin-2(1H)-ones/thiones DHPMs 

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Chemistry, Karaj BranchIslamic Azad UniversityKarajIran

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