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A simple and facile synthesis of tricyclic-fused pyrimido[4,5-b]indol-2-amines

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Abstract

In the present investigation, a simple and facile synthetic strategy for the construction of a series of structurally interesting tricyclic-fused N-alkyl-9H-pyrimido[4,5-b]indol-2-amines has been successfully achieved. Our synthesis, based on the annulation reaction between readily available 2-chloroindole-3-carbaldehydes or 3-acetyl-2-chloroindoles and guanidine nitrate using KOH as the base in refluxing EtOH medium, has the attractive features such as mild and economical reaction conditions and easy handing with lesser impact on the environment.

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Acknowledgements

The project was financially supported by the National Natural Science Foundation of China (Nos. 21402011 and 21476028) and the Natural Science Foundation of Liaoning Province (No. 201602006).

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  1. Institute of Superfine Chemicals, Bohai University, Keji Street, Jinzhou, 121000, People’s Republic of China

    Wentao Gao, Dongfang Wang & Yang Li

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  1. Wentao Gao
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Correspondence to Yang Li.

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Gao, W., Wang, D. & Li, Y. A simple and facile synthesis of tricyclic-fused pyrimido[4,5-b]indol-2-amines. Mol Divers 21, 831–840 (2017). https://doi.org/10.1007/s11030-017-9757-4

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