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Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water

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Abstract

An efficient and facile green synthesis of spirooxindole derivatives bearing pyrano[2,3-c]pyrazole moiety has been achieved via a \(\mathrm{CeO}_{2}\)-NPs catalyzed four-component reaction in water. The protocol offers an environmentally benign and effective approach to highly functionalized and biologically interesting spiro[indoline-3,4\(^\prime \)-pyrano[2,3-c]pyrazole] derivatives. The synthesized compounds exhibit potent antioxidant and antibacterial activities.

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Acknowledgments

This work was supported by the 2014 Yeungnam University Research Grant (215A555002).

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Authors and Affiliations

  1. School of Chemical Engineering, Yeungnam University, Gyeongsan, 712-749, Republic of Korea

    Rajeev Shrestha, Kavita Sharma & Yong Rok Lee

  2. Department of Food Science and Technology, Yeungnam University, Gyeongsan, 712-749, Republic of Korea

    Young-Jung Wee

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  1. Rajeev Shrestha
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Shrestha, R., Sharma, K., Lee, Y.R. et al. Cerium oxide-catalyzed multicomponent condensation approach to spirooxindoles in water. Mol Divers 20, 847–858 (2016). https://doi.org/10.1007/s11030-016-9670-2

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