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Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles

Molecular Diversity volume 19, pages 577–623 (2015)Cite this article

Abstract

In this report, we review the current chemistry progress and in particular the synthesis approaches of tri- and tetra-substituted imidazoles.

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Acknowledgments

The authors are thankful to the Department of Chemistry for the honors and moral support, and the Alzahra University Research Council for financial supports.

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Authors and Affiliations

  1. Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran

    Majid M. Heravi, Mansoureh Daraie & Vahideh Zadsirjan

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  1. Majid M. Heravi
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  2. Mansoureh Daraie
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  3. Vahideh Zadsirjan
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Correspondence to Majid M. Heravi.

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This article is dedicated to Professor Abbas Shafiee, who taught me how to synthesize, Clotrimazole (Structure 4 of this review) at bench scale, in 1982.

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Heravi, M.M., Daraie, M. & Zadsirjan, V. Current advances in the synthesis and biological potencies of tri- and tetra-substituted 1H-imidazoles. Mol Divers 19, 577–623 (2015). https://doi.org/10.1007/s11030-015-9590-6

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Keywords

  • Tri-aryl-1\(H\)-imidazoles
  • Tetra-aryl-1\(H\)-imidazoles
  • Biological activity