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Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol

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Abstract

A variety of organocatalysts has been screened for the synthesis of arylaminonaphthols. It has been shown that (N,N-dimethylethanolamine) is a highly efficient organocatalyst for the direct synthesis of a novel class of arylaminonaphthols via three-component condensation of 2-naphthol, aldehydes, and arylamines under solvent-free conditions. Mild, one-pot, and green reaction conditions, relatively short reaction times and good yields make this protocol highly significant. 25 new compounds have been synthesized by this method.

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Acknowledgments

We thank research affairs of the University of Tabriz for financial support.

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Authors and Affiliations

  1. Department of Organic and Biochemistry, Faculty of Chemistry, University of Tabriz, 5166614766, Tabriz, Iran

    Aziz Shahrisa, Reza Teimuri-Mofrad & Mahdi Gholamhosseini-Nazari

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  1. Aziz Shahrisa
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  2. Reza Teimuri-Mofrad
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  3. Mahdi Gholamhosseini-Nazari
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Correspondence to Aziz Shahrisa.

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Shahrisa, A., Teimuri-Mofrad, R. & Gholamhosseini-Nazari, M. Synthesis of a new class of Betti bases by the Mannich-type reaction: efficient, facile, solvent-free and one-pot protocol. Mol Divers 19, 87–101 (2015). https://doi.org/10.1007/s11030-014-9559-x

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